Disodium pamidronate for treating severe hypercalcemia in a hemodialysis patient

被引:9
作者
Trimarchi, Hernan
Lombi, Fernando
Forrester, Mariano
Elizondo, Cristina
Sawinski, Deirdre
Pereyra, Horacio
Freixas, Emilio
机构
[1] Hosp Britan Buenos Aires, Dept Med, Renal Sect, RA-1280 Buenos Aires, DF, Argentina
[2] Hosp Britan Buenos Aires, Dept Med, Renal Transplant Unit, RA-1280 Buenos Aires, DF, Argentina
[3] Hosp Britan Buenos Aires, Dept Med, Renal Pancreas Transplant Unit, RA-1280 Buenos Aires, DF, Argentina
[4] Hosp Britan Buenos Aires, Div Nephrol, Buenos Aires, DF, Argentina
[5] Hosp Britan Buenos Aires, Internal Med Serv, Buenos Aires, DF, Argentina
[6] Columbia Univ, Med Ctr, New York, NY USA
来源
NATURE CLINICAL PRACTICE NEPHROLOGY | 2006年 / 2卷 / 08期
关键词
bisphosphonates; hemodialysis; hypercalcemia; multiple myeloma; pamidronate;
D O I
10.1038/ncpneph0248
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Background A 48-year-old man with a recent diagnosis of multiple myeloma and rapidly progressive oliguric end-stage renal disease requiring hemodialysis, presented with a serum calcium concentration of 3.4 mmol/l (13.6 mg/dl). Investigations Serum laboratory analysis, electroencephalogram, MRI of the brain and bone marrow, and kidney biopsies. Diagnosis Hypercalcemia secondary to multiple myeloma. Management Short-term intravenous disodium pamidronate therapy (30 mg daily) and daily monitoring of serum calcium concentration.
引用
收藏
页码:459 / 463
页数:5
相关论文
共 15 条
[1]   Hypercalcemia and electrolyte disturbances in malignancy [J].
Barri, YM ;
Knochel, JP .
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 1996, 10 (04) :775-+
[2]   Bisphosphonates: Mechanisms of action [J].
Fleisch, H .
ENDOCRINE REVIEWS, 1998, 19 (01) :80-100
[3]   A new insight into the formation of osteolytic lesions in multiple myeloma [J].
Glass, DA ;
Patel, MS ;
Karsenty, G .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (26) :2479-2480
[4]  
Lindberg JS, 1999, SEMIN NEPHROL, V19, P115
[5]   Acute effect of pamidronate on PTH secretion in postmenopausal. Hemodialysis patients with secondary hyperparathyroidism [J].
Lu, KC ;
Yeung, LK ;
Lin, SH ;
Lin, YF ;
Chu, P .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2003, 42 (06) :1221-1227
[6]   Efficacy of bisphosphonates in the management of skeletal complications of bone metastases and selection of clinical endpoints [J].
Major, PP ;
Cook, R .
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 2002, 25 (06) :S10-S18
[7]  
Markowitz GS, 2001, J AM SOC NEPHROL, V12, P1164, DOI 10.1681/ASN.V1261164
[8]   HYPERCALCEMIA DUE TO CALCIUM-BINDING BY A POLYMERIC IGA K-PARAPROTEIN [J].
PEARCE, CJ ;
HINE, TJ ;
PEEK, K .
ANNALS OF CLINICAL BIOCHEMISTRY, 1991, 28 :229-234
[9]  
POPOVTZER M, 1992, RENAL ELECTROLYTE DI, P287
[10]   Multiple myeloma: Diagnosis and treatment [J].
Rajkumar, SV ;
Kyle, RA .
MAYO CLINIC PROCEEDINGS, 2005, 80 (10) :1371-1382