Cardiac spectroscopy: techniques, indications and clinical results

被引:19
作者
Beer, M [1 ]
机构
[1] Univ Wurzburg, Inst Diagnost Radiol, D-97080 Wurzburg, Germany
关键词
magnetic resonance; MR spectroscopy; heart; metabolism; high-energy phosphates; fatty acids; absolute quantification; hypertrophy; failure; ischemia; involvement; state-of-art reviews;
D O I
10.1007/s00330-004-2279-3
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Cardiac MR spectroscopy allows the non-invasive assessment of metabolic processes. In contrast to numerous experimental applications, the clinical use of MRS is still restricted to specialized centers of expertise. However, during the last 10 years, several technical improvements as well as new clinical applications have been introduced, which might change this fact. This article focuses on (1) these recent technical advances such as reproducible quantification methods and dedicated data acquisition as well as postprocessing methods, (2) outlines emerging clinical indications and (3) summarizes available clinical studies. Basic principles of cardiac metabolism are presented, and discussed in the context of recent clinical papers. Finally, the impact of the new highest-field magnets-3 T and beyond-is discussed under the perspectives for the future clinical role of MR spectroscopy.
引用
收藏
页码:1034 / 1047
页数:14
相关论文
共 92 条
[1]   NORMAL AND DIFFUSELY ABNORMAL MYOCARDIUM IN HUMANS - FUNCTIONAL AND METABOLIC CHARACTERIZATION WITH P-31 MR SPECTROSCOPY AND CINE MR IMAGING [J].
AUFFERMANN, W ;
CHEW, WM ;
WOLFE, CL ;
TAVARES, NJ ;
PARMLEY, WW ;
SEMELKA, RC ;
DONNELLY, T ;
CHATTERJEE, K ;
HIGGINS, CB .
RADIOLOGY, 1991, 179 (01) :253-259
[2]  
BARNES PR, 1999, BRAIN, V120, P1699
[3]   Determination of absolute concentrations of cardiac high-energy phosphates using 31P-MR-spectroscopy and SLOOP in healthy and diseased myocardium. [J].
Beer, M ;
Landschütz, W ;
Meininger, M ;
Seyfarth, T ;
Viehrig, M ;
Sandstede, J ;
Pabst, T ;
Kenn, W ;
Horn, M ;
Harre, K ;
von Kienlin, M ;
Neubauer, S ;
Hahn, D .
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN, 1999, 171 (01) :65-68
[4]  
Beer M, 2000, RADIOLOGE, V40, P162, DOI 10.1007/s001170050026
[5]   Absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium measured noninvasively with 31P-SLOOP magnetic resonance spectroscopy [J].
Beer, M ;
Seyfarth, T ;
Sandstede, J ;
Landschütz, W ;
Lipke, C ;
Köstler, H ;
von Kienlin, M ;
Harre, K ;
Hahn, D ;
Neubauer, S .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 40 (07) :1267-1274
[6]   Cardiac metabolism and function in patients with multiple sclerosis:: A combined 31P-MR-spectroscopy and MRI study [J].
Beer, M ;
Sandstede, J ;
Weilbach, F ;
Spindler, M ;
Buchner, S ;
Krug, A ;
Köstler, H ;
Pabst, T ;
Kenn, W ;
Landschütz, W ;
von Kienlin, M ;
Toyka, KV ;
Ertl, G ;
Gold, R ;
Hahn, D .
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN, 2001, 173 (05) :399-404
[7]   Altered energy metabolism after myocardial infarction assessed by 31P-MR-spectroscopy in humans [J].
Beer, M ;
Sandstede, J ;
Landschütz, W ;
Viehrig, M ;
Harre, K ;
Horn, M ;
Meininger, M ;
Pabst, T ;
Kenn, W ;
Haase, A ;
von Kienlin, M ;
Neubauer, S ;
Hahn, D .
EUROPEAN RADIOLOGY, 2000, 10 (08) :1323-1328
[8]  
BEER M, 2002, FORTSCHR RONTGENS S4, V174, P286
[9]   Aortic valve replacement in patients with aortic valve stenosis improves myocardial metabolism and diastolic function [J].
Beyerbacht, HP ;
Lamb, HJ ;
van der Laarse, A ;
Vliegen, HW ;
Leujes, F ;
Hazekamp, MG ;
de Roos, A ;
van der Wall, EE .
RADIOLOGY, 2001, 219 (03) :637-643