Efficacy of ramipril versus enalapril in patients with mild to moderate essential hypertension

被引:0
|
作者
Yasky, J
Verho, M
Erasmus, TP
Luus, HG
Angela, M
Grandin, L
Akbary, MA
Rangoonwala, B
机构
[1] UNIV ORANGE FREE STATE,FARMOVS RES CTR,DIV BIOMETRY,ZA-9300 BLOEMFONTEIN,SOUTH AFRICA
[2] UNIV NACL CUYO,FAC CIENCIAS MED,DEPT MED INTERNA,RA-5500 MENDOZA,ARGENTINA
[3] HOECHST AG,CLIN RES,D-6230 FRANKFURT,GERMANY
来源
BRITISH JOURNAL OF CLINICAL PRACTICE | 1996年 / 50卷 / 06期
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中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This double-blind, randomised, cross-over study investigated the antihypertensive efficacy of ramipril and enalapril was completed by 30 patients with mild-to-moderate essential hypertension. After a four-week placebo run-in phase, the patients received either 2.5mg ramipril or 10mg enalapril once daily for four weeks. The dosages were increased to 5mg ramipril and 20mg enalapril for a further four weeks. After a placebo washout phase of four weeks, the patients were crossed over to the alternative treatment. The decrease in average 24-hour ambulatory diastolic blood pressure from week 0 to week 8 was 1.6mmHg greater with ramipril than enalapril (90% confidence interval 0.6-2.7mmHg). The corresponding reduction in for systolic blood pressure was also greater with ramipril than enalapril by 2.4mmHg (90% confidence interval: 0.5-4.2mmHg). For the difference in the drop of 24-hour ambulatory diastolic blood pressure between ramipril and enalapril the fewer level of the 90% confidence interval (CI) is above the clinically relevant difference of -3mmHg. This is an indication that ramipril (2.5 and 5mg dose) is at least as effective as enalapril (10 and 20mg dose) in decreasing blood pressure in patients with mild-to-moderate essential hypertension. The duration of adequate antihypertensive effect was relatively long for both ramipril and enalapril; however, ramipril tended to have a more prolonged antihypertensive effect. Ramipril had a higher diastolic and systolic trough/peak ratio than enalapril, resulting in a more uniform antihypertensive effect over the 24-hour treatment period. Both ramipril and enalapril were well tolerated and the two treatment groups had similar safety profiles.
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页码:302 / &
页数:7
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