Asymmetric direct aldol reaction assisted by water and a proline-derived tetrazole catalyst

被引：556
|
作者：
Torii, H
Nakadai, M
Ishihara, K
Saito, S [1 ]
Yamamoto, H
机构：
[1] Nagoya Univ, Inst Adv Res, Nagoya, Aichi 4648602, Japan
[2] Nagoya Univ, Grad Sch Sci, Nagoya, Aichi 4648602, Japan
[3] Univ Chicago, Dept Chem, Chicago, IL 60637 USA
[4] Nagoya Univ, Grad Sch Engn, Nagoya, Aichi 4648603, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 15期
关键词：
aldol reaction; amines; asymmetric catalysis; tetrazole; water;
D O I：
10.1002/anie.200352724
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Just add water to improve the performance of direct aldol reactions like that shown. Previously, aldehydes with high water-affinity or -solubility were considered unsuitable for asymmetric synthesis.
引用
收藏
页码：1983 / 1986
页数：4
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