Hybrid gadolinium oxide nanoparticles combining imaging and therapy

被引：60

作者：

Bridot, Jean-Luc ^{[1
]}

Dayde, David ^{[2
]}

Riviere, Charlotte ^{[3
]}

Mandon, Celine ^{[4
]}

Billotey, Claire ^{[4
]}

Lerondel, Stephanie ^{[5
]}

Sabattier, Roland ^{[6
]}

Cartron, Guillaume ^{[7
]}

Le Pape, Alain ^{[5
]}

Blondiaux, Gilbert ^{[8
]}

Janier, Marc ^{[4
]}

Perriat, Pascal ^{[9
]}

Roux, Stephane ^{[1
]}

Tillement, Olivier ^{[1
]}

机构：

[1] Univ Lyon 1, CNRS, UMR 5620, Lab Physicochim Mat Luminescents, F-69622 Villeurbanne, France

[2] Fac Med Tours, Immunol Lab, IPGA, EA 3853, F-37032 Tours, France

[3] Univ Lyon 1, CNRS, UMR 5586, Lab Phys Mat Condensee & Nanostruct, F-69622 Villeurbanne, France

[4] Univ Lyon 1, CNRS, UMR 5515, INSERM,INSA Lyon,Lab CREATIS Animage,U630, F-69622 Villeurbanne, France

[5] CNRS, UPS 44, Ctr Distribut Typage & Archivage Anim, F-45071 Orleans, France

[6] Ctr Hosp Reg Orleans, Serv Radiol, F-45000 Orleans, France

[7] Ctr Hosp Univ Lapeyronnie, INSERM, U847, Serv Hematol & Biotherapie, F-34295 Montpellier, France

[8] CNRS, CERI, F-45071 Orleans 2, France

[9] Inst Natl Sci Appl, CNRS, UMR 5510, MATEIS, F-69621 Villeurbanne, France

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2009年 / 19卷 / 16期

关键词：

NEUTRON-CAPTURE THERAPY; CONTRAST AGENTS; ACTIVE ESTERS; CANCER; DELIVERY; TUMOR; NANOTECHNOLOGY; DERIVATIVES; MRI;

D O I：

10.1039/b815836c

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The cytotoxicity of luminescent paramagnetic gadolinium oxide nanoparticles activated by harmless thermal neutron irradiation was evaluated on a luciferase coding gene transfected lymphome cells (EL4-Luc). Cellular uptake of nanoparticles was determined by fluorescence and magnetic resonance imaging and by ICP-MS analyses while the metabolic activity of irradiated EL4-Luc cells was monitored by bioluminescence. The alteration of the irradiated cells depends both on neutron irradiation dose and on gadolinium content within cells. In addition to their dual modality imaging ability, the application of these multifunctional particles for neutron capture therapy can be envisaged.

引用

页码：2328 / 2335

页数：8

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