Hybrid gadolinium oxide nanoparticles combining imaging and therapy

被引：60

作者：

Bridot, Jean-Luc ^{[1
]}

Dayde, David ^{[2
]}

Riviere, Charlotte ^{[3
]}

Mandon, Celine ^{[4
]}

Billotey, Claire ^{[4
]}

Lerondel, Stephanie ^{[5
]}

Sabattier, Roland ^{[6
]}

Cartron, Guillaume ^{[7
]}

Le Pape, Alain ^{[5
]}

Blondiaux, Gilbert ^{[8
]}

Janier, Marc ^{[4
]}

Perriat, Pascal ^{[9
]}

Roux, Stephane ^{[1
]}

Tillement, Olivier ^{[1
]}

机构：

[1] Univ Lyon 1, CNRS, UMR 5620, Lab Physicochim Mat Luminescents, F-69622 Villeurbanne, France

[2] Fac Med Tours, Immunol Lab, IPGA, EA 3853, F-37032 Tours, France

[3] Univ Lyon 1, CNRS, UMR 5586, Lab Phys Mat Condensee & Nanostruct, F-69622 Villeurbanne, France

[4] Univ Lyon 1, CNRS, UMR 5515, INSERM,INSA Lyon,Lab CREATIS Animage,U630, F-69622 Villeurbanne, France

[5] CNRS, UPS 44, Ctr Distribut Typage & Archivage Anim, F-45071 Orleans, France

[6] Ctr Hosp Reg Orleans, Serv Radiol, F-45000 Orleans, France

[7] Ctr Hosp Univ Lapeyronnie, INSERM, U847, Serv Hematol & Biotherapie, F-34295 Montpellier, France

[8] CNRS, CERI, F-45071 Orleans 2, France

[9] Inst Natl Sci Appl, CNRS, UMR 5510, MATEIS, F-69621 Villeurbanne, France

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2009年 / 19卷 / 16期

关键词：

NEUTRON-CAPTURE THERAPY; CONTRAST AGENTS; ACTIVE ESTERS; CANCER; DELIVERY; TUMOR; NANOTECHNOLOGY; DERIVATIVES; MRI;

D O I：

10.1039/b815836c

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The cytotoxicity of luminescent paramagnetic gadolinium oxide nanoparticles activated by harmless thermal neutron irradiation was evaluated on a luciferase coding gene transfected lymphome cells (EL4-Luc). Cellular uptake of nanoparticles was determined by fluorescence and magnetic resonance imaging and by ICP-MS analyses while the metabolic activity of irradiated EL4-Luc cells was monitored by bioluminescence. The alteration of the irradiated cells depends both on neutron irradiation dose and on gadolinium content within cells. In addition to their dual modality imaging ability, the application of these multifunctional particles for neutron capture therapy can be envisaged.

引用

页码：2328 / 2335

页数：8

共 38 条

[1] AN EASY PREPARATION OF HAPTEN ACTIVE ESTERS VIA SOLID SUPPORTED EDAC
ADAMCZYK, M
FISHPAUGH, JR
MATTINGLY, PG
[J]. TETRAHEDRON LETTERS, 1995, 36 (46) : 8345 - 8346
[2] Drug delivery systems: Entering the mainstream
Allen, TM
Cullis, PR
[J]. SCIENCE, 2004, 303 (5665) : 1818 - 1822
[3] Boron neutron capture therapy of cancer: Current status and future prospects
Barth, RF
Coderre, JA
Vicente, MGH
Blue, TE
[J]. CLINICAL CANCER RESEARCH, 2005, 11 (11) : 3987 - 4002
[4] BORONATED STARBURST DENDRIMER MONOCLONAL-ANTIBODY IMMUNOCONJUGATES - EVALUATION AS A POTENTIAL DELIVERY SYSTEM FOR NEUTRON-CAPTURE THERAPY
BARTH, RF
ADAMS, DM
SOLOWAY, AH
ALAM, F
DARBY, MV
[J]. BIOCONJUGATE CHEMISTRY, 1994, 5 (01) : 58 - 66
[5] Synthesis and properties of europium-based phosphors on the manometer scale:: Eu2O3, Gd2O3:Eu, and Y2O3:Eu
Bazzi, R
Flores, MA
Louis, C
Lebbou, K
Zhang, W
Dujardin, C
Roux, S
Mercier, B
Ledoux, G
Bernstein, E
Perriat, P
Tillement, O
[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2004, 273 (01) : 191 - 197
[6] Synthesis and luminescent properties of sub-5-nm lanthanide oxides nanoparticles
Bazzi, R
Flores-Gonzalez, MA
Louis, C
Lebbou, K
Dujardin, C
Brenier, A
Zhang, W
Tillement, O
Bernstein, E
Perriat, P
[J]. JOURNAL OF LUMINESCENCE, 2003, 102 : 445 - 450
[7] Polyhedral boron derivatives of porphyrins and phthalocyanines
Bregadze, VI
Sivaev, IB
Gabel, D
Wöhrle, D
[J]. JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 2001, 5 (11) : 767 - 781
[8] Hybrid gadolinium oxide nanoparticles:: Multimodal contrast agents for in vivo imaging
Bridot, Jean-Luc
Faure, Anne-Charlotte
Laurent, Sophie
Riviere, Charlotte
Billotey, Claire
Hiba, Bassem
Janier, Marc
Josserand, Veronique
Coll, Jean-Luc
Vander Elst, Luce
Muller, Robert
Roux, Stephane
Perriat, Pascal
Tillement, Olivier
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (16) : 5076 - 5084
[9] Strategies for increasing the sensitivity of gadolinium based MRI contrast agents
Caravan, Peter
[J]. CHEMICAL SOCIETY REVIEWS, 2006, 35 (06) : 512 - 523
[10] A cellular Trojan horse for delivery of therapeutic nanoparticles into tumors
Choi, Mi-Ran
Stanton-Maxey, Katie J.
Stanley, Jennifer K.
Levin, Carly S.
Bardhan, Rizia
Akin, Demir
Badve, Sunil
Sturgis, Jennifer.
Robinson, J. Paul
Bashir, Rashid
Halas, Naomi J.
Clare, Susan E.
[J]. NANO LETTERS, 2007, 7 (12) : 3759 - 3765

← 1 2 3 4 →