Deficits in ultrasonic vocalization development and production following neonatal hypoxic ischemic insult

被引:2
作者
Doran, Sarah J. [1 ]
Jandzinski, Mike [1 ]
Patrizz, Anthony [1 ,2 ]
Trammel, Cassandra [1 ]
Sharmeen, Romana [2 ]
Mamun, Abdullah A. [2 ]
Capozzi, Lori A. [1 ]
Venna, Venugopal Reddy [1 ,2 ]
Liu, Fudong [1 ,2 ]
McCullough, Louise D. [1 ,2 ]
机构
[1] Univ Connecticut, Hlth Ctr, Dept Neurosci, Farmington, CT 06030 USA
[2] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Neurol, Houston, TX 77030 USA
基金
美国国家卫生研究院;
关键词
Ultrasonic vocalization; Hypoxic ischemic encephalopathy; Neonates; AUDITORY PROCESSING DEFICITS; ENCEPHALOPATHY; OUTCOMES; INJURY; ASPHYXIA; LANGUAGE; CHILDREN; RATS;
D O I
10.1016/j.bbr.2019.111931
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Neonatal hypoxic ischemia encephalopathy (HIE) leads to major deficits in language development. While clinically there is a known correlation in the degree of HIE injury and subsequent language disability, there are no treatments beyond speech and language therapy; therefore, experimental studies with a HIE animal model to test new interventions and therapeutics are warranted. Neonatal rodents normally ultrasonically vocalize at postnatal day 7 (PND 7) to PND 14 in response to removal from their mothers. At 6-8 weeks of age juvenile male rodents ultrasonically vocalize in response to exposure to a mature female mouse. Changes in ultrasonic vocalization (USV) production after neonatal brain injury, such ashypoxic ischemia (HI), have not been studied. This study examines the acute and long-term ultrasonic vocalization ability of mice after HI at PND 10. Pups were subjected to HI, sham, or naive conditions; where in HI and sham surgeries the right common carotid artery was exposed, in the HI this artery was double ligated. The HI and sham pups were then exposed to60minof hypoxia. Naive pups did not undergo surgery and were subjected to60minof room air. At 3 days following surgery, HI and sham pups vocalize less than nonsurgical naive controls; yet "juvenile" mice of 6-8 weeks old that underwent HI at PND 10 vocalize less than sham and naive mice. We conclude that HI injury has significant impact on later adult vocalization.
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页数:6
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