Innovative Therapies in Ewing Sarcoma

被引：10
作者：
Teresa Amaral, Ana [1 ]
Luis Ordonez, Jose [1 ]
Pastora Otero-Motta, Ana [1 ]
Garcia-Dominguez, Daniel J. [1 ]
Victoria Sevillano, Maria [1 ]
de Alava, Enrique [1 ,2 ]
机构：
[1] Ctr Invest Canc IBSAL CIC, Ctr Invest Canc, Inst Biomed Res Salamanca, Mol Pathol Program, Salamanca, Spain
[2] Hosp Univ Virgen del Rocio IBiS, Dept Pathol, Seville, Spain
来源：
ADVANCES IN ANATOMIC PATHOLOGY | 2014年 / 21卷 / 01期
关键词：
Ewing sarcoma; therapy; clinical trials; animal model; NATURAL-KILLER-CELLS; FACTOR-I-RECEPTOR; HISTONE DEACETYLASE INHIBITORS; GROWTH-FACTOR; HOMOLOGOUS RECOMBINATION; NEDD8-ACTIVATING ENZYME; MONOCLONAL-ANTIBODY; ZOLEDRONIC ACID; PROGNOSTIC IMPACT; TUMOR-GROWTH;
D O I：
10.1097/PAP.0000000000000003
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Ewing Sarcoma is a developmental tumor characterized by balanced chromosomal translocations and formation of new fusion genes, which are the main hallmark of this rare entity. Despite the vast knowledge regarding the molecular aspects of this rare malignancy obtained in the last few years, including the discovery of new therapeutic targets, many questions still remain open. In this review we focus on the research on targeted therapies in this malignancy, and discussed some bottlenecks related to this such as the possible role of pathologists, the availability of samples, the lack of appropriate animal models, and the resources needed to carry out preclinical and clinical research.
引用
收藏
页码：44 / 62
页数：19
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