The Treatment of Neuromyelitis Optica

被引：37

作者：

Kowarik, Markus C. ^{[1
,3
]}

Soltys, John ^{[2
,3
]}

Bennett, Jeffrey L. ^{[1
,2
,3
]}

机构：

[1] Univ Colorado Denver, Dept Neurol, Denver, CO USA

[2] Univ Colorado Denver, Dept Ophthalmol, Denver, CO USA

[3] Univ Colorado Denver, Neurosci Program, Denver, CO USA

来源：

JOURNAL OF NEURO-OPHTHALMOLOGY | 2014年 / 34卷 / 01期

基金：

美国国家卫生研究院;

关键词：

COMPLEMENT-DEPENDENT CYTOTOXICITY; INTERFERON-BETA TREATMENT; MULTIPLE-SCLEROSIS; PLASMA-EXCHANGE; IMMUNOGLOBULIN-G; NMO-IGG; RANDOMIZED-TRIAL; T-CELLS; ANTI-AQUAPORIN-4; ANTIBODY; AQUAPORIN-4; EXPRESSION;

D O I：

10.1097/WNO.0000000000000102

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neuromyelitis optica (NMO) is an autoimmune disorder of the central nervous system directed against astrocytes. Initially diagnosed in individuals with monophasic or relapsing optic neuritis and transverse myelitis, NMO is now recognized as a demyelinating disorder with pleiotropic presentations due to the identification of a specific autoantibody response against the astrocyte water channel aquaporin-4 in the majority of individuals. As visual impairment and neurologic dysfunction in NMO are commonly severe, aggressive treatment of relapses and prophylactic immunomodulatory therapy are the focus of treatment. Although there are no approved treatments for NMO, medications and therapeutic interventions for acute and chronic treatment have been the subject of retrospective study and case reports. The goal of this review is to familiarize the reader with biologic and clinical data supporting current treatments in NMO and highlight future strategies based on advancements in our understanding of NMO pathogenesis.

引用

页码：70 / 82

页数：13

共 124 条

[31] Aquaporin-4-binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2 [J].

Hinson, Shannon R. ;

Roemer, Shanu F. ;

Lucchinetti, Claudia F. ;

Fryer, James P. ;

Kryzer, Thomas J. ;

Chamberlain, Jayne L. ;

Howe, Charles L. ;

Pittock, Sean J. ;

Lennon, Vanda A. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (11) :2473-2481

[32] Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytes [J].

Hinson, Shannon R. ;

Romero, Michael F. ;

Popescu, Bogdan F. Gh. ;

Lucchinetti, Claudia F. ;

Fryer, James P. ;

Wolburg, Hartwig ;

Fallier-Becker, Petra ;

Noell, Susan ;

Lennon, Vanda A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (04) :1245-1250

[33] Increased migration and metastatic potential of tumor cells expressing aquaporin water channels [J].

Hu, Jie ;

Verkman, A. S. .

FASEB JOURNAL, 2006, 20 (11) :1892-+

[34] Quantitative assays for anti-aquaporin-4 antibody with subclass analysis in neuromyelitis optica [J].

Isobe, Noriko ;

Yonekawa, Tomomi ;

Matsushita, Takuya ;

Kawano, Yuji ;

Masaki, Katsuhisa ;

Yoshimura, Satoshi ;

Fichna, Jakub ;

Chen, Shu ;

Furmaniak, Jadwiga ;

Smith, Bernard Rees ;

Kira, Jun-ichi .

MULTIPLE SCLEROSIS JOURNAL, 2012, 18 (11) :1541-1551

[35]

Izaki Shoko, 2013, Rinsho Shinkeigaku, V53, P513

[36] Treatment of Neuromyelitis Optica With Rituximab Retrospective Analysis of 25 Patients [J].

Jacob, Anu ;

Weinshenker, Brian G. ;

Violich, Ivo ;

McLinskey, Nancy ;

Krupp, Lauren ;

Fox, Robert J. ;

Wingerchuk, Dean M. ;

Boggild, Mike ;

Constantinescu, Cris S. ;

Miller, Aaron ;

De Angelis, Tracy ;

Matiello, Marcelo ;

Cree, Bruce A. C. .

ARCHIVES OF NEUROLOGY, 2008, 65 (11) :1443-1448

[37]

Jacob A, 2009, ARCH NEUROL-CHICAGO, V66, P1128, DOI 10.1001/archneurol.2009.175

[38] Cerebrospinal fluid findings in aquaporin-4 antibody positive neuromyelitis optica: Results from 211 lumbar punctures [J].

Jarius, S. ;

Paul, F. ;

Franciotta, D. ;

Ruprecht, K. ;

Ringelstein, M. ;

Bergamaschi, R. ;

Rommer, P. ;

Kleiter, I. ;

Stich, O. ;

Reuss, R. ;

Rauer, S. ;

Zettl, U. K. ;

Wandinger, K. P. ;

Melms, A. ;

Aktas, O. ;

Kristoferitsch, W. ;

Wildemann, B. .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2011, 306 (1-2) :82-90

[39] Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients [J].

Jarius, Sven ;

Ruprecht, Klemens ;

Wildemann, Brigitte ;

Kuempfel, Tania ;

Ringelstein, Marius ;

Geis, Christian ;

Kleiter, Ingo ;

Kleinschnitz, Christoph ;

Berthele, Achim ;

Brettschneider, Johannes ;

Hellwig, Kerstin ;

Hemmer, Bernhard ;

Linker, Ralf A. ;

Lauda, Florian ;

Mayer, Christoph A. ;

Tumani, Hayrettin ;

Melms, Arthur ;

Trebst, Corinna ;

Stangel, Martin ;

Marziniak, Martin ;

Hoffmann, Frank ;

Schippling, Sven ;

Faiss, Juergen H. ;

Neuhaus, Oliver ;

Ettrich, Barbara ;

Zentner, Christian ;

Guthke, Kersten ;

Hofstadt-van Oy, Ulrich ;

Reuss, Reinhard ;

Pellkofer, Hannah ;

Ziemann, Ulf ;

Kern, Peter ;

Wandinger, Klaus P. ;

Bergh, Florian Then ;

Boettcher, Tobias ;

Langel, Stefan ;

Liebetrau, Martin ;

Rommer, Paulus S. ;

Niehaus, Sabine ;

Muench, Christoph ;

Winkelmann, Alexander ;

Zettl U, Uwe K. ;

Metz, Imke ;

Veauthier, Christian ;

Sieb, Joern P. ;

Wilke, Christian ;

Hartung, Hans P. ;

Aktas, Orhan ;

Paul, Friedemann .

JOURNAL OF NEUROINFLAMMATION, 2012, 9

[40] Plasma exchange for severe attacks of CNS demyelination: Predictors of response [J].

Keegan, M ;

Pineda, AA ;

McClelland, RL ;

Darby, CH ;

Rodriguez, M ;

Weinshenker, BG .

NEUROLOGY, 2002, 58 (01) :143-146

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