Autophagy in Zika Virus Infection: A Possible Therapeutic Target to Counteract Viral Replication

被引：28

作者：

Gratton, Rossella ^{[1
]}

Agrelli, Almerinda ^{[2
]}

Tricarico, Paola Maura ^{[1
]}

Brandao, Lucas ^{[3
]}

Crovella, Sergio ^{[1
,4
]}

机构：

[1] IRCCS Burlo Garofolo, Dept Adv Diagnost, Via Istria 65-1, I-34137 Trieste, Italy

[2] Univ Fed Pernambuco, Lab Immunopathol Keizo Asami, Ave Prof Moraes Rego,1235 Cidade Univ, BR-50670901 Recife, PE, Brazil

[3] Univ Fed Pernambuco, Dept Pathol, Ave Prof Moraes Rego,1235 Cidade Univ, BR-50670901 Recife, PE, Brazil

[4] Univ Trieste, Dept Med Surg & Hlth Sci, Str Fiume 447, I-34149 Trieste, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 05期

关键词：

Zika virus; autophagy; Akt-mTOR; innate immunity; therapeutic targets; HUMAN DENDRITIC CELLS; WEST NILE VIRUS; DENGUE-VIRUS; DC-SIGN; PHOSPHATIDYLSERINE RECEPTORS; INHIBITION; INNATE; FLAVIVIRUS; PROTEIN; CHLOROQUINE;

D O I：

10.3390/ijms20051048

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Zika virus (ZIKV) still constitutes a public health concern, however, no vaccines or therapies are currently approved for treatment. A fundamental process involved in ZIKV infection is autophagy, a cellular catabolic pathway delivering cytoplasmic cargo to the lysosome for degradationconsidered as a primordial form of innate immunity against invading microorganisms. ZIKV is thought to inhibit the Akt-mTOR signaling pathway, which causes aberrant activation of autophagy promoting viral replication and propagation. It is therefore appealing to study the role of autophagic molecular effectors during viral infection to identify potential targets for anti-ZIKV therapeutic intervention.

引用

页数：21

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