Deletion of Class A Scavenger Receptor Deteriorates Obesity-Induced Insulin Resistance in Adipose Tissue

被引：24

作者：

Zhu, Xudong ^{[1
]}

Zong, Guijuan ^{[1
]}

Zhu, Liu ^{[1
]}

Jiang, Yuchen ^{[1
]}

Ma, Ke ^{[1
]}

Zhang, Hanwen ^{[1
]}

Zhang, Yan ^{[1
]}

Bai, Hui ^{[1
]}

Yang, Qing ^{[1
]}

Ben, Jingjing ^{[1
]}

Li, Xiaoyu ^{[1
]}

Xu, Yong ^{[1
]}

Chen, Qi ^{[1
]}

机构：

[1] Nanjing Med Univ, Atherosclerosis Res Ctr, Collaborat Innovat Ctr Cardiovasc Dis Translat Me, Key Lab Cardiovasc Dis & Mol Intervent, Nanjing, Jiangsu, Peoples R China

来源：

DIABETES | 2014年 / 63卷 / 02期

基金：

中国国家自然科学基金;

关键词：

LOW-DENSITY-LIPOPROTEIN; TOLL-LIKE RECEPTORS; MACROPHAGE POLARIZATION; ALTERNATIVE ACTIVATION; METABOLIC DISEASE; LIPID UPTAKE; MICE; LYSOPHOSPHATIDYLCHOLINE; PROTEIN; INFLAMMATION;

D O I：

10.2337/db13-0815

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic low-grade inflammation, particularly in the adipose tissue, orchestrates obesity-induced insulin resistance. In this process, polarized activation of macrophages plays a crucial role. However, how macrophages contribute to insulin resistance remains obscure. Class A scavenger receptor (SR-A) is a pattern recognition receptor primarily expressed in macrophages. Through a combination of in vivo and in vitro studies, we report here that deletion of SR-A resulted in reduced insulin sensitivity in obese mice. The anti-inflammatory virtue of SR-A was accomplished by favoring M2 macrophage polarization in adipose tissue. Moreover, we demonstrate that lysophosphatidylcholine (LPC) served as an obesity-related endogenous ligand for SR-A promoting M2 macrophage polarization by activation of signal transducer and activator of transcription 6 signaling. These data have unraveled a clear mechanistic link between insulin resistance and inflammation mediated by the LPC/SR-A pathway in macrophages.

引用

页码：562 / 577

页数：16

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