Evaluation of Serum Vitamin B12 Levels in Type 2 Diabetes Patients Metformin Treated

被引：0
|
作者：
Gherasim, Andreea [1 ,2 ]
Cianga, Petru [1 ,4 ]
Anisie, Ecaterina [4 ]
Arhire, Lidia Iuliana [1 ,2 ]
Mihalache, Laura [1 ,2 ]
Nita, Otilia [1 ,2 ]
Gavril, Radu Sebastian [1 ,3 ]
Graur, Mariana [1 ,2 ]
机构：
[1] Grigore T Popa Univ Med & Pharm, Fac Med, 16 Univ Str, Iasi 700115, Romania
[2] Sf Spiridon Clin Cty Emergency Hosp, Diabet Nutr & Metab Dis Clin, 1 Independentei Blvd, Iasi 700111, Romania
[3] Clin Rehabil Hosp, Internal Med, 14 Pantelimon Halipa Str, Iasi 700614, Romania
[4] Sf Spiridon Clin Cty Emergency Hosp, Imunol, 1 Independenei Blvd, Iasi 700111, Romania
来源：
REVISTA DE CHIMIE | 2018年 / 69卷 / 05期
关键词：
B-12; deficiency; type 2 diabetes mellitus; metformin; COBALAMIN DEFICIENCY; PERIPHERAL NEUROPATHY; PREVALENCE; MELLITUS; SUPPLEMENTATION; ASSOCIATION; DIAGNOSIS; THERAPY; UPDATE; RISK;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Vitamin B-12 deficiency is a condition characterized by neurological or haematological abnormalities, and may occur after treatment with metformin in patients with type 2 diabetes. We evaluated 119 patients with type 2 diabetes mellitus, treated with oral antidiabetic agents. The parameters evaluated were: vitamin B-12 intake, anthropometric data, disease history, neuropathic complications evaluation (using MNSI), serum vitamin B-12, glycated hemoglobin, erythrocyte indices. Vitamin B-12 deficiency was defined at values below 194 pg/mL. We have found a prevalence of vitamin B-12 deficiency of 13.9% in the patients treated with metformin (10.9% in all participants). B-12 levels were not correlated with age, metformin dose or duration of treatment. Patients using B-12 supplements had higher B-12 serum levels (472.50 vs. 329.22, p <= 0.05).
引用
收藏
页码：1207 / 1212
页数：6
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