IGF-1C domain-modified chitosan hydrogel accelerates cutaneous wound healing by promoting angiogenesis

被引：17
作者：
Li, Qiong [1 ]
Cui, Jian [2 ]
Huang, Haoyan [3 ]
Yue, Zhiwei [3 ]
Chang, Yuqiao [1 ]
Li, Nana [1 ]
Han, Zhibo [4 ,5 ]
Han, Zhong-chao [4 ,5 ]
Guo, Zhikun [1 ]
Li, Zongjin [1 ,3 ]
机构：
[1] Xinxiang Med Univ, Henan Key Lab Med Tissue Regenerat, Xinxiang, Henan, Peoples R China
[2] Peoples Hosp Rizhao, Dept Intens Care Unit ICU, Rizhao, Shandong, Peoples R China
[3] Nankai Univ, Sch Med, Tianjin, Peoples R China
[4] AmCellGene Co Ltd, Tianjin Key Lab Engn Technol Cell Pharmaceut, Natl Engn Res Ctr Cell Prod, Tianjin, Peoples R China
[5] Jiangxi Engn Res Ctr Stem Cell, Shangrao, Jiangxi, Peoples R China
来源：
FUTURE MEDICINAL CHEMISTRY | 2020年 / 12卷 / 13期
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
angiogenesis; C domain of IGF-1; hydrogel; remodeling; wound healing; MESENCHYMAL STEM-CELLS; NITRIC-OXIDE; SUBSTANCE-P; C-DOMAIN; DRESSINGS; DELIVERY; THERAPY; MICE;
D O I：
10.4155/fmc-2020-0071
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Background: Complete regeneration after skin injury remains a critical clinical challenge. Hydrogels, modified with growth factors or mimicking peptides, have been applied for functional tissue regeneration by increasing the bioactivity of engineered matrices. Methodology & results: We synthesized an injectable biological hydrogel, C domain of IGF-1 (IGF-1C)-modified chitosan (CS-IGF-1C) hydrogel. Mouse model of cutaneous wound healing was established to investigate whether this hydrogel could promote wound healing. Our results demonstrated that CS-IGF-1C hydrogel exhibited superior proangiogenic effects, resulting in accelerated wound closure and improved extracellular matrix remodeling. Bioluminescence imaging and histology analysis confirmed the proangiogenic role of CS-IGF-1C hydrogel. Conclusion: CS-IGF-1C hydrogel could accelerate cutaneous wound healing by stimulating angiogenesis. Graphical abstract
引用
收藏
页码：1239 / 1251
页数：13
相关论文
共 32 条
[1]   Chitosan-based hydrogels for controlled, localized drug delivery [J].
Bhattarai, Narayan ;
Gunn, Jonathan ;
Zhang, Miqin .
ADVANCED DRUG DELIVERY REVIEWS, 2010, 62 (01) :83-99
[2]   Pre-vascularization Enhances Therapeutic Effects of Human Mesenchymal Stem Cell Sheets in Full Thickness Skin Wound Repair [J].
Chen, Lei ;
Xing, Qi ;
Zhai, Qiyi ;
Tahtinen, Mitchell ;
Zhou, Fei ;
Chen, Lili ;
Xu, Yingbin ;
Qi, Shaohai ;
Zhao, Feng .
THERANOSTICS, 2017, 7 (01) :117-131
[3]   Enhanced proangiogenic potential of mesenchymal stem cell-derived exosomes stimulated by a nitric oxide releasing polymer [J].
Du, Wei ;
Zhang, Kaiyue ;
Zhang, Shuaiqiang ;
Wang, Ran ;
Nie, Yan ;
Tao, Hongyan ;
Han, Zhibo ;
Liang, Lu ;
Wang, Di ;
Liu, Jianfeng ;
Liu, Na ;
Han, Zhongchao ;
Kong, Deling ;
Zhao, Qiang ;
Li, Zongjin .
BIOMATERIALS, 2017, 133 :70-81
[4]   Translational applications of molecular imaging in cardiovascular disease and stem cell therapy [J].
Du, Wei ;
Tao, Hongyan ;
Zhao, Shihua ;
He, Zuo-Xiang ;
Li, Zongjin .
BIOCHIMIE, 2015, 116 :43-51
[5]   IGF-1 C Domain-Modified Hydrogel Enhances Cell Therapy for AKI [J].
Feng, Guowei ;
Zhang, Jimin ;
Li, Yang ;
Nie, Yan ;
Zhu, Dashuai ;
Wang, Ran ;
Liu, Jianfeng ;
Gao, Jie ;
Liu, Na ;
He, Ningning ;
Du, Wei ;
Tao, Hongyan ;
Che, Yongzhe ;
Xu, Yong ;
Kong, Deling ;
Zhao, Qiang ;
Li, Zongjin .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2016, 27 (08) :2357-2369
[6]   Enzyme-controllable delivery of nitric oxide from a molecular hydrogel [J].
Gao, Jie ;
Zheng, Wenting ;
Zhang, Jimin ;
Guan, Di ;
Yang, Zhimou ;
Kong, Deling ;
Zhao, Qiang .
CHEMICAL COMMUNICATIONS, 2013, 49 (80) :9173-9175
[7]   Chitosan based hydrogels and their applications for drug delivery in wound dressings: A review [J].
Hamedi, Hamid ;
Moradi, Sara ;
Hudson, Samuel M. ;
Tonelli, Alan E. .
CARBOHYDRATE POLYMERS, 2018, 199 :445-460
[8]   Polysaccharides derived from Lycium barbarum suppress IGF-1-induced angiogenesis via PI3K/HIF-1α/VEGF signalling pathways in MCF-7 cells [J].
Huang, Xu ;
Zhang, Qing-Yuan ;
Jiang, Qiu-Ying ;
Kang, Xin-Mei ;
Zhao, Ling .
FOOD CHEMISTRY, 2012, 131 (04) :1479-1484
[9]   Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles [J].
Keeney, Michael ;
Deveza, Lorenzo ;
Yang, Fan .
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2013, (79) :e50736
[10]   Molecular imaging for assessment of mesenchymal stem cells mediated breast cancer therapy [J].
Leng, Liang ;
Wang, Yuebing ;
He, Ningning ;
Wang, Di ;
Zhao, Qianjie ;
Feng, Guowei ;
Su, Weijun ;
Xu, Yang ;
Han, Zhongchao ;
Kong, Deling ;
Cheng, Zhen ;
Xiang, Rong ;
Li, Zongjin .
BIOMATERIALS, 2014, 35 (19) :5162-5170
1234