Niche specific insulin signaling mediated by insulin receptor substrate 2 promotes proliferation, survival and differentiation of cancer progenitor cells in human models of liver tumorigenesis - A novel role for "localized insulin signaling" in HCC?

被引:0
|
作者
Manzano Nunez, Fatima [1 ,2 ]
Acosta Umanzor, Carlos [1 ,2 ]
Leal Tassias, Aranzazu [1 ]
Burks, Deborah J. [1 ,2 ]
Noon, Luke A. [1 ,2 ]
机构
[1] CIPF, Valencia, Spain
[2] Ctr Invest Biomed Red CIBER, Valencia, Spain
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
691
引用
收藏
页码:550A / 551A
页数:2
相关论文
共 27 条
  • [1] Insulin is required for the differentiation and proliferation of hepatocyte progenitor cells in vitro: A novel role for insulin receptor substrate 2
    Noon, Luke A.
    Martinez-Romero, Alicia
    O'Connor, Jose E.
    Corlu, Anne
    Bouille, Pascale
    Guillouzco, Christiane
    Burks, Deborah J.
    HEPATOLOGY, 2013, 58 : 1005A - 1005A
  • [2] Upregulated insulin receptor tyrosine kinase substrate promotes the proliferation of colorectal cancer cells via the bFGF/AKT signaling pathway
    Wang, Song
    Liu, Zheng
    Ma, Yi-Ming
    Guan, Xu
    Jiang, Zheng
    Sun, Peng
    Liu, En-Rui
    Zhang, Yu-Kun
    Wang, Hong-Ying
    Wang, Xi-Shan
    GASTROENTEROLOGY REPORT, 2021, 9 (02): : 166 - 175
  • [3] Insulin receptor tyrosine kinase substrate (IRTKS) promotes the tumorigenesis of pancreatic cancer via PI3K/AKT signaling
    Lu, Yu
    Zhou, Xin-Yuan
    Zhou, Cheng-Liang
    Liu, Jie
    Yong, Tao
    Fan, Yong
    Wang, Chen
    HUMAN CELL, 2022, 35 (06) : 1885 - 1899
  • [4] Insulin receptor tyrosine kinase substrate (IRTKS) promotes the tumorigenesis of pancreatic cancer via PI3K/AKT signaling
    Yu Lu
    Xin-Yuan Zhou
    Cheng-Liang Zhou
    Jie Liu
    Tao Yong
    Yong Fan
    Chen Wang
    Human Cell, 2022, 35 : 1885 - 1899
  • [5] Progesterone crosstalks with insulin-like growth factor signaling in breast cancer cells via induction of insulin receptor substrate-2
    Cui, XJ
    Lazard, Z
    Zhang, P
    Hopp, TA
    Lee, AV
    ONCOGENE, 2003, 22 (44) : 6937 - 6941
  • [6] Progesterone crosstalks with insulin-like growth factor signaling in breast cancer cells via induction of insulin receptor substrate-2
    Xiaojiang Cui
    ZaWaunyka Lazard
    Ping Zhang
    Torsten A Hopp
    Adrian V Lee
    Oncogene, 2003, 22 : 6937 - 6941
  • [7] Endothelial Cell Mediated Promotion of Ciliated Cell Differentiation of Human Airway Basal Cells via Insulin and Insulin-Like Growth Factor 1 Receptor Mediated Signaling
    Gomi, Kazunori
    Tang, Yongjiang
    Arbelaez, Vanessa
    Crystal, Ronald G.
    Walters, Matthew S.
    STEM CELL REVIEWS AND REPORTS, 2017, 13 (02) : 309 - 317
  • [8] Endothelial Cell Mediated Promotion of Ciliated Cell Differentiation of Human Airway Basal Cells via Insulin and Insulin-Like Growth Factor 1 Receptor Mediated Signaling
    Kazunori Gomi
    Yongjiang Tang
    Vanessa Arbelaez
    Ronald G. Crystal
    Matthew S. Walters
    Stem Cell Reviews and Reports, 2017, 13 : 309 - 317
  • [9] Role of MEK1/ERK1/2 Signaling in Human Insulin- and Insulin Glargine-Induced Proliferation of T24 Human Bladder Cancer Cells
    Liu, Shanying
    Li, Yan
    Liang, Ying
    Liu, Dan
    Liang, Weiwen
    Yan, Li
    DIABETES, 2011, 60 : A677 - A677
  • [10] Insulin receptor substrate-1 is the predominant signaling molecule activated by insulin-like growth factor-I, insulin, and interleukin-4 in estrogen receptor-positive human breast cancer cells
    Jackson, JG
    White, MF
    Yee, D
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (16) : 9994 - 10003