Renal-Limited Thrombotic Microangiopathy due to Bevacizumab Therapy for Metastatic Colorectal Cancer: A Case Report

被引：9

作者：

Toriu, Naoya ^{[1
,2
]}

Sekine, Akinari ^{[1
,2
]}

Mizuno, Hiroki ^{[1
,2
]}

Hasegawa, Eiko ^{[1
,2
]}

Yamanouchi, Masayuki ^{[1
,2
]}

Hiramatsu, Rikako ^{[1
,2
]}

Hayami, Noriko ^{[1
,2
]}

Hoshino, Junichi ^{[1
,2
]}

Kawada, Masahiro ^{[1
,2
]}

Suwabe, Tatsuya ^{[1
,2
]}

Sumida, Keiichi ^{[1
,2
]}

Sawa, Naoki ^{[1
,2
]}

Takaichi, Kenmei ^{[1
,2
,4
]}

Ohashi, Kenichi ^{[3
,6
]}

Fujii, Takeshi ^{[3
]}

Matoba, Shuichiro ^{[5
]}

Ubara, Yoshifumi ^{[1
,2
,4
]}

机构：

[1] Toranomon Gen Hosp, Nephrol Ctr, Tokyo, Japan

[2] Toranomon Gen Hosp, Dept Rheumatol, Tokyo, Japan

[3] Toranomon Gen Hosp, Dept Pathol, Tokyo, Japan

[4] Okinaka Mem Inst Med Res, Tokyo, Japan

[5] Toranomon Gen Hosp, Colorectal Surg Unit, Dept Digest Surg, Tokyo, Japan

[6] Yokohama City Univ, Grad Sch Med, Dept Pathol, Yokohama, Kanagawa, Japan

来源：

CASE REPORTS IN ONCOLOGY | 2019年 / 12卷 / 02期

关键词：

Thrombotic microangiopathy; Bevacizumab; Nephrotic syndrome; Colorectal cancer; KIDNEY-DISEASES; VEGF;

D O I：

10.1159/000500716

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

An 88-year-old Japanese man received bevacizumab for colorectal cancer with liver and peritoneal metastasis, during which nephrotic range proteinuria occurred (7.66 g/day). Renal biopsy showed endothelial damage with subendothelial swelling and a double contour of the glomerular basement membrane, which indicated a diagnosis of thrombotic microangiopathy (TMA). After bevacizumab was stopped, proteinuria decreased to 1 g/day. During the clinical course, this patient had no extrarenal manifestations. This case suggests that renal injury induced by bevacizumab is characterized by nephrotic range proteinuria and histological TMA, and is a renal-limited condition that differs from systemic TMA related to thrombotic thrombocytopenic purpura.

引用

页码：391 / 400

页数：10

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