Renal-Limited Thrombotic Microangiopathy due to Bevacizumab Therapy for Metastatic Colorectal Cancer: A Case Report

被引：9

作者：

Toriu, Naoya ^{[1
,2
]}

Sekine, Akinari ^{[1
,2
]}

Mizuno, Hiroki ^{[1
,2
]}

Hasegawa, Eiko ^{[1
,2
]}

Yamanouchi, Masayuki ^{[1
,2
]}

Hiramatsu, Rikako ^{[1
,2
]}

Hayami, Noriko ^{[1
,2
]}

Hoshino, Junichi ^{[1
,2
]}

Kawada, Masahiro ^{[1
,2
]}

Suwabe, Tatsuya ^{[1
,2
]}

Sumida, Keiichi ^{[1
,2
]}

Sawa, Naoki ^{[1
,2
]}

Takaichi, Kenmei ^{[1
,2
,4
]}

Ohashi, Kenichi ^{[3
,6
]}

Fujii, Takeshi ^{[3
]}

Matoba, Shuichiro ^{[5
]}

Ubara, Yoshifumi ^{[1
,2
,4
]}

机构：

[1] Toranomon Gen Hosp, Nephrol Ctr, Tokyo, Japan

[2] Toranomon Gen Hosp, Dept Rheumatol, Tokyo, Japan

[3] Toranomon Gen Hosp, Dept Pathol, Tokyo, Japan

[4] Okinaka Mem Inst Med Res, Tokyo, Japan

[5] Toranomon Gen Hosp, Colorectal Surg Unit, Dept Digest Surg, Tokyo, Japan

[6] Yokohama City Univ, Grad Sch Med, Dept Pathol, Yokohama, Kanagawa, Japan

来源：

CASE REPORTS IN ONCOLOGY | 2019年 / 12卷 / 02期

关键词：

Thrombotic microangiopathy; Bevacizumab; Nephrotic syndrome; Colorectal cancer; KIDNEY-DISEASES; VEGF;

D O I：

10.1159/000500716

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

An 88-year-old Japanese man received bevacizumab for colorectal cancer with liver and peritoneal metastasis, during which nephrotic range proteinuria occurred (7.66 g/day). Renal biopsy showed endothelial damage with subendothelial swelling and a double contour of the glomerular basement membrane, which indicated a diagnosis of thrombotic microangiopathy (TMA). After bevacizumab was stopped, proteinuria decreased to 1 g/day. During the clinical course, this patient had no extrarenal manifestations. This case suggests that renal injury induced by bevacizumab is characterized by nephrotic range proteinuria and histological TMA, and is a renal-limited condition that differs from systemic TMA related to thrombotic thrombocytopenic purpura.

引用

页码：391 / 400

页数：10

共 50 条

[21] Renal-limited thrombotic microangiopathy and acute interstitial nephritis with a single dose of quinine
Anjelo, Jobert
Rao, Nitesh
David, Vinoi G.
Otto, Sophia
Russ, Graeme
CLINICAL KIDNEY JOURNAL, 2014, 7 (03): : 311 - 313
[22] EltrombopagAcute renal failure secondary to renal limited thrombotic microangiopathy: case report
Reactions Weekly, 2021, 1841 (1) : 104 - 104
[23] RENAL THROMBOTIC MICROANGIOPATHY TRIGGERED BY LUNG CANCER IN LIMITED SSC-A CASE REPORT-
Kise, T.
Yokogawa, N.
Shimada, K.
Sugii, S.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2014, 32 (02) : S138 - S138
[24] GemcitabineRenal limited thrombotic microangiopathy: case report
Reactions Weekly, 2023, 1982 (1) : 199 - 199
[25] Thrombotic microangiopathy due to cancer is an oncological emergency: a case report
Blot, E
Marie, I
Delastre, O
Cailleux, N
Pouillart, P
Levesque, H
Courtois, H
REVUE DE MEDECINE INTERNE, 1999, 20 (05): : 448 - 449
[26] Intraarticular hemorrhage due to bevacizumab in a patient with metastatic colorectal cancer: a case report
Mukremin Uysal
Sema Sezgin Goksu
Hasan Senol Coskun
Burhan Savas
Mustafa Ozdogan
Hakan Bozcuk
Journal of Medical Case Reports, 6 (1)
[27] Bevacizumab/sorafenibNephrotic syndrome and thrombotic microangiopathy: case report
Reactions Weekly, 2016, 1618 (1) : 43 - 43
[28] Bevacizumab/LenvatinibDrug induced thrombotic microangiopathy: case report
Reactions Weekly, 2024, 2036 (1) : 91 - 91
[29] RENAL LIMITED THROMBOTIC MICROANGIOPATHY: A PEDIATRIC CASE.
Yavascan, Onder
Demir, Belde Kasap
Alparslan, Caner
Karadeniz, Tugba
Alaygut, Demet
Soyaltin, Eren
Mutlubas, Fatma
PEDIATRIC NEPHROLOGY, 2018, 33 (10) : 1838 - 1838
[30] Case Report: Maintenance Bevacizumab in Metastatic Colorectal Cancer
Sponziello, F.
Calvani, N.
Chetri, M. C.
Rizzo, P.
Fedele, P.
Orlando, L.
D'Amico, M.
Nacci, A.
Schiavone, P.
Cinefra, M.
Cinieri, S.
ONCOLOGY, 2009, 77 : 160 - 160

← 1 2 3 4 5 →