Synthetic studies with 13-deoxybaccatin III

被引:10
作者
Ahn, YM
Vander Velde, DG
Georg, GI [1 ]
机构
[1] Univ Kansas, Dept Med Chem, Lawrence, KS 66045 USA
[2] Univ Kansas, Drug Discovery Program, Higuchi Biosci Ctr, Lawrence, KS 66045 USA
关键词
D O I
10.1021/jo011183q
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An efficient synthesis of 13-epi-7-O-(triethylsilyl)baccatin III from 13-deoxybaccatin III is described. Oxidation of 13-deoxy-7-O-(triethylsilyl)baccatin III with tert-butyl peroxide, followed by reduction with SmI2, produced 13-epi-7-O-(triethylsilyl)baccatin III in good overall yield. The preparation of 13-oxo-7-O-(triethylsilyl)baccatin III from 13-epi-7-O-(triethylsilyl)baccatin III using tetrapropylammonium perruthenate and N-methylmorpholine N-oxide is also reported.
引用
收藏
页码:7140 / 7143
页数:4
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