Toward intelligent nanosize bioreactors: A pH-switchable, channel-equipped, functional polymer nanocontainer

被引：217
作者：
Broz, Pavel
Driamov, Sergey
Ziegler, Joerg
Ben-Haim, Nadav
Marsch, Stephan
Meier, Wolfgang
Hunziker, Patrick
机构：
[1] Univ Basel Hosp, Med Intens Care Unit, CH-4031 Basel, Switzerland
[2] Univ Basel, Dept Chem, CH-4056 Basel, Switzerland
[3] Univ Basel, Natl Ctr Competence Res Nanoscale Sci, CH-4056 Basel, Switzerland
来源：
NANO LETTERS | 2006年 / 6卷 / 10期
关键词：
D O I：
10.1021/nl0619305
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
To develop an intelligent sensor-effector functionality on the nanoscale, a pH-switchable, controlled nanoreactor based on amphiphilic copolymer membranes was built. The nanovesicles were equipped with bacterial transmembrane ompF pore proteins and the pH-sensitive enzyme acid phosphatase, resulting in a switchable substrate processing at pH 4-6.5. Ideal pH and substrate concentrations for the reaction were determined experimentally. In future, the reactor might be used for self-regulating targeted diagnostic and therapeutic applications in medicine.
引用
收藏
页码：2349 / 2353
页数：5
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