Microwave synthesis of 2-[(E)-2-(1H-indol-3-yl)vinyl] hetarenes

被引：5
|
作者：
Aksenov, Alexander V. [1 ]
Nadein, Oleg N. [1 ]
Aksenov, Nicolai A. [1 ]
Skomorokhov, Anton A. [1 ]
Aksenova, Inna V. [1 ]
Rubin, Michael A. [1 ,2 ]
机构：
[1] North Caucasus Fed Univ, 1 Pushkin St, Stavropol 355009, Russia
[2] Univ Kansas, 1251 Wescoe Hall Dr, Lawrence, KS 66045 USA
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2015年 / 51卷 / 10期
关键词：
benzoxazole; indole; pyridine; quinoline; condensation; microwave synthesis; CELL IMAGING PROBES; 3-SUBSTITUTED; 2-QUINOLONES; MESSENGER-RNA; STYRYL DYES; IN-VIVO; EXPRESSION; INDOLES; DNA;
D O I：
10.1007/s10593-015-1788-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new highly efficient method for the condensation of (indol-3-yl)carbaldehydes with 2-methylazoles and 2-methylazines under activation with microwave irradiation is developed. The method provides high yields of structural scaffolds of bishetarylethylene fluorescent sensors that found widespread application in medicinal, bioorganic, and pharmaceutical chemistry.
引用
收藏
页码：865 / 868
页数：4
相关论文
共 50 条
  • [1] Microwave synthesis of 2-[(E)-2-(1H-indol-3-yl)vinyl]hetarenes
    Alexander V. Aksenov
    Oleg N. Nadein
    Nicolai A. Aksenov
    Anton A. Skomorokhov
    Inna V. Aksenova
    Michael A. Rubin
    Chemistry of Heterocyclic Compounds, 2015, 51 : 865 - 868
  • [2] Automated Multistep Continuous Flow Synthesis of 2-(1H-Indol-3-yl)thiazole Derivatives
    Pagano, Nicholas
    Heil, Marintha L.
    Cosford, Nicholas D. P.
    SYNTHESIS-STUTTGART, 2012, 44 (16): : 2537 - 2546
  • [3] Aminopalladation-Triggered Carbene Insertion Reaction: Synthesis of 2-(1H-Indol-3-yl)acetates
    Hu, Ziwei
    Luo, Shuang
    Zhu, Qiang
    ADVANCED SYNTHESIS & CATALYSIS, 2015, 357 (05) : 1060 - 1064
  • [4] The Synthesis and Biological Evaluation of 2-(1H-Indol-3-yl)quinazolin-4(3H)-One Derivatives
    Mendogralo, Elena Y.
    Nesterova, Larisa Y.
    Nasibullina, Ekaterina R.
    Shcherbakov, Roman O.
    Tkachenko, Alexander G.
    Sidorov, Roman Y.
    Sukonnikov, Maxim A.
    Skvortsov, Dmitry A.
    Uchuskin, Maxim G.
    MOLECULES, 2023, 28 (14):
  • [5] A Facile Route towards the Synthesis of 2-(1H-indol-3-yl)-acetamides Using 1,1-Carbonyldiimidazole
    Kanwal
    Khan, Khalid Mohammed
    Fatima, Bibi
    Bano, Bilquees
    Salar, Uzma
    JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN, 2016, 38 (04): : 771 - 774
  • [6] Simple and efficient Knoevenagel synthesis of (E)-2-((1H-indol-3-yl) methylene)-3-oxoindolylnitrile catalysed by PPh3
    Venkatanarayana, M.
    Dubey, P. K.
    JOURNAL OF CHEMICAL SCIENCES, 2011, 123 (05) : 609 - 614
  • [7] An efficient and practical synthesis of 2-((1H-indol-3-yl)(aryl)methyl)malononitriles under ultrasound irradiation
    Li, Ji-Tai
    Lin, Zhi-Ping
    ULTRASONICS SONOCHEMISTRY, 2008, 15 (04) : 265 - 268
  • [8] Simple, novel, and efficient synthesis of ethyl 2-(2-(1H-indol-3-yl)benzo[d]thiazol-3(2H)-yl)-2-cyanoacetate or acetate via a three-component reaction
    Nassiri, Mahmoud
    Jalili Milani, Forough
    JOURNAL OF CHEMICAL RESEARCH, 2021, 45 (5-6) : 526 - 530
  • [9] TEMPO-catalyzed oxidative dimerization and cyanation of indoles for the synthesis of 2-(1H-indol-3-yl)-3-oxoindoline-2-carbonitriles
    Jiang, Lili
    Peng, Xiangjun
    Huang, Panpan
    Chen, Zhengwang
    Liu, Liangxian
    TETRAHEDRON, 2017, 73 (11) : 1389 - 1396
  • [10] Green Synthesis of Ethyl 2-[(1H-Indol-3-yl)(phenyl)methyl]-3-oxobutanoate Derivatives Using NiO Nanocatalysts
    Pratibha, R.
    Das, R.
    Serdaroglu, G.
    Pandit, J.
    Bahe, A. K.
    Mishra, A. K.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2024, 94 (08) : 2023 - 2037
12345