Chiral recognition in adrenergic receptor binding mimics prepared by molecular imprinting

被引:0
|
作者
Ramstrom, O [1 ]
Yu, C [1 ]
Mosbach, K [1 ]
机构
[1] LUND UNIV,CTR CHEM,DEPT PURE & APPL BIOCHEM,S-22100 LUND,SWEDEN
关键词
molecular recognition; molecular imprinting; adrenergic receptors;
D O I
10.1002/(SICI)1099-1352(199634/12)9:5/6<691::AID-JMR322>3.0.CO;2-G
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Molecularly imprinted polymers were prepared against the adrenomimetic agents ephedrine and pseudoephedrine. These compounds each incorporate two chiral centres, The polymers were evaluated with respect to enantiodiscrimination of various adrenergic ligands. The selectivity of the polymeric binding sites for the imprinted molecules was very high, and it was found that binding of both the enantiomeric and diastereomeric isomers of the imprint species were effectively obstructed, In addition, it was found that these polymers could selectively recognize the enantiomers of the endogenous adrenergic ligand epinephrine as well as several beta-adrenergic blockers. These observations suggest that these polymers effectively mimic the recognition patterns exhibited by natural adrenergic receptors.
引用
收藏
页码:691 / 696
页数:6
相关论文
共 50 条
  • [31] MOLECULAR IMPRINTING - MOLECULARLY IMPRINTED POLYMERS - THEIR USE IN ENANTIOMERIC RESOLUTION, AS ANTIBODY-BINDING MIMICS AND AS CATALYSIS
    MOSBACH, K
    PROTEIN ENGINEERING, 1995, 8 : 54 - 54
  • [32] Enzyme mimics based on molecular imprinting polymers: Applications and perspective
    Chen, Tao
    Li, Aihua
    Zhang, Aitang
    Wei, Shuang
    Zhang, Mian
    Wu, Zilong
    Jung, Kenward
    Boyer, Cyrille
    Liu, Jingquan
    Chemical Engineering Journal, 1600, 499
  • [33] Synthetic creatinine receptor:: Imprinting of a Lewis acidic zinc(II)cyclen binding site to shape its molecular recognition selectivity
    Subat, M
    Borovik, AS
    König, B
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (10) : 3185 - 3190
  • [34] Molecular Imprinting for Substrate Selectivity and Enhanced Activity of Enzyme Mimics
    Zhang, Zijie
    Liu, Biwu
    Liu, Juewen
    SMALL, 2017, 13 (07)
  • [35] DRUG ASSAY USING ANTIBODY MIMICS MADE BY MOLECULAR IMPRINTING
    VLATAKIS, G
    ANDERSSON, LI
    MULLER, R
    MOSBACH, K
    NATURE, 1993, 361 (6413) : 645 - 647
  • [36] Synthetic Creatinine Receptor: Imprinting of a Lewis Acidic Zinc(II)cyclen Binding Site to Shape Its Molecular Recognition Selectivity
    König, B. (Burkhard.Koenig@chemie.uni-regensburg.de), 1600, American Chemical Society (126):
  • [37] Carboxylated polysulfone membranes having a chiral recognition site induced by an alternative molecular imprinting technique
    Yoshikawa, Masakazu
    Izumi, Jun-Ichiro
    Ooi, Takashi
    Kitao, Toshio
    Guiver, Michael D.
    Robertson, Gilles P.
    Polymer Bulletin, 40 (4-5): : 517 - 524
  • [38] Carboxylated polysulfone membranes having a chiral recognition site induced by an alternative molecular imprinting technique
    Masakazu Yoshikawa
    Jun-ichiro Izumi
    Takashi Ooi
    Toshio Kitao
    Michael D. Guiver
    Gilles P. Robertson
    Polymer Bulletin, 1998, 40 : 517 - 524
  • [39] Carboxylated polysulfone membranes having a chiral recognition site induced by an alternative molecular imprinting technique
    Yoshikawa, M
    Izumi, J
    Ooi, T
    Kitao, T
    Guiver, MD
    Robertson, GP
    POLYMER BULLETIN, 1998, 40 (4-5) : 517 - 524
  • [40] Enzyme mimics based on molecular imprinting polymers: Applications and perspective
    Chen, Tao
    Li, Aihua
    Zhang, Aitang
    Wei, Shuang
    Zhang, Mian
    Wu, Zilong
    Jung, Kenward
    Boyer, Cyrille
    Liu, Jingquan
    CHEMICAL ENGINEERING JOURNAL, 2024, 499