Inhibition of amyloid fibril formation by peptide analogues modified with α-aminoisobutyric acid

Breaking up is not hard to do with an α-aminoisobutyric (Aib) acid β-breaker, which has a remarkably restricted conformation. A novel approach to the inhibition of amyloid formation was developed that uses peptides modified with Aib (see figure). The similarity of Aib to hydrophobic amino acids, often found in amyloidogenic sequences, allows its integration into recognition motifs.