A Divergent Approach to the Synthesis of 3-Substituted-2-pyrazolines: Suzuki Cross-Coupling of 3-Sulfonyloxy-2-pyrazolines

被引：18

作者：

Grimm, Jonathan B. ^{[1
]}

Wilson, Kevin J. ^{[1
]}

Witter, David J. ^{[1
]}

机构：

[1] Merck Res Labs, Dept Chem, Boston, MA 02115 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 16期

关键词：

IMIDOYL CHLORIDES; ARYL; DERIVATIVES; ACIDS; CATALYSTS; DESIGN; SCOPE; MILD;

D O I：

10.1021/jo9011859

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The efficient Suzuki cross-coupling of pyrazoline nonaflates with organoboron reagents was achieved to afford diverse 3-substituted-2-pyrazolines in excellent yield. The nonaflates displayed improved reactivity over the corresponding triflates and smoothly coupled to a variety of aryl- and heteroarylboronic acids. This process and its broad scope constitute a rapid, divergent strategy for the synthesis of elaborated 2-pyrazolines that are not readily obtained via conventional methods.

引用

页码：6390 / 6393

页数：4

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