The biological role of D-glucaric acid and its derivatives: Potential use in medicine

被引:0
|
作者
Zoltaszek, Robert [2 ]
Hanausek, Margaret [2 ]
Kilianska, Zofia M. [1 ]
Walaszek, Zbigniew [2 ]
机构
[1] Uniwersytet Lodzki, Katedra Cytobiochem, Zaklad Biochem Med, PL-90237 Lodz, Poland
[2] Univ Texas Hlth Sci Ctr San Antonio, Dept Pharmacol, San Antonio, TX 78229 USA
来源
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ | 2008年 / 62卷
关键词
D-glucaric acid; D-glucaro-1,4-lactone; beta-glucuronidase; cancers; inflammation; apoptosis; oxidative stress;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
D-glucaric acid is a natural non-toxic compound produced in small amounts by mammals, including humans. In mammals, D-glucaric acid and D-glucaro-1,4-lactone are end-products of the D-glucuronic acid pathway. The enzyme D-glucuronolactone dehydrogenase has been found to be responsible for the oxidation of the lactone of D-glucuronic acid to D-glucaro-1,4;6,3-dilactone. This dilactone hydrolyzes spontaneously in aqueous solution to D-glucaro-1,4-lactone, a potent glucuronidase inhibitor. D-glucaric acid is also found in many fruits and vegetables, with the highest concentrations found in grapefruits, apples, oranges, and cruciferous vegetables. beta-glucuronidase is present in the circulation and probably all vertebrate tissues and is capable of hydrolyzing glucuronide conjugates. This enzyme is also produced by colonic microflora. Elevated beta-glucuronidase activity is associated with an increased risk for various cancers, particularly hormone-dependent cancers such as breast and prostate cancer. D-glucaro-1,4-lactone increases detoxification of carcinogens and tumor promoters by inhibiting beta-glucuronidase and preventing the hydrolysis of their glucuronides. D-glucaro-1,4-lactone was found to be formed from supplemented D-glucarate salt in the stomach and it is absorbed from the intestinal track, transported with the blood to different internal organs, and excreted in urine and, to a lesser extent, in bile. D-glucaro-1,4-lactone and its precursors exert their anticancer action in part through alterations in steroidogenesis accompanied by changes in the hormonal environment and proliferative status of the target organs. D-glucarates not only suppress cell proliferation and inflammation, but also induce apoptosis. By supplementing D-glucarates, one can favor the body's natural defense mechanism for eliminating carcinogens and tumor promoters and their effects.
引用
收藏
页码:451 / 462
页数:12
相关论文
共 50 条
  • [31] D-GLUCARIC ACID EXCRETION - AGE AND SEX RELATED DIFFERENCES
    HANNA, FM
    FAHIM, M
    HALL, DG
    FEDERATION PROCEEDINGS, 1970, 29 (02) : A294 - +
  • [32] Identification of Pathways for Production of d-Glucaric Acid by Pseudogluconobacter saccharoketogenes
    Tetsuya Ito
    Hisaharu Masaki
    Koki Fujita
    Hiromi Murakami
    Motohiro Shizuma
    Taro Kiso
    Takaaki Kiryu
    Applied Biochemistry and Biotechnology, 2024, 196 : 1876 - 1895
  • [33] Urinary D-glucaric acid excretion in idiopathic neonatal jaundice
    Sung, RYT
    Pang, CP
    Lyon, A
    Loong, PL
    Davies, DP
    CHINESE MEDICAL JOURNAL, 1996, 109 (03) : 201 - 205
  • [34] D-GLUCARIC ACID EXCRETION DURING CHENODEOXYCHOLATE THERAPY FOR GALLSTONES
    BUDILLON, G
    DARIENZO, A
    MAZZACCA, G
    PARRILLI, G
    CAPUANO, G
    LANCET, 1978, 1 (8057): : 206 - 206
  • [35] Urinary D-glucaric acid excretion in idiopathic neonatal jaundice
    RYT Sung
    CP Pang
    A Lyon
    PL Loong
    DP Davies
    CHINESE MEDICAL JOURNAL, 1996, (03) : 205 - 205
  • [36] Synthesis of Crystalline and Amphiphilic Polymers from D-Glucaric Acid
    Wu, Yuxin
    Enomoto-Rogers, Yukiko
    Masaki, Hisaharu
    Iwata, Tadahisa
    ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2016, 4 (07): : 3812 - 3819
  • [37] INCREASED URINARY-EXCRETION OF D-GLUCARIC ACID IN ALCOHOLISM
    MEZEY, E
    RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY, 1976, 15 (04): : 735 - 742
  • [38] Identification of Pathways for Production of d-Glucaric Acid by Pseudogluconobacter saccharoketogenes
    Ito, Tetsuya
    Masaki, Hisaharu
    Fujita, Koki
    Murakami, Hiromi
    Shizuma, Motohiro
    Kiso, Taro
    Kiryu, Takaaki
    APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2024, 196 (04) : 1876 - 1895
  • [39] BIOSYNTHESIS OF D-GLUCARIC ACID IN NEEDLES OF LARIX-DECIDUA
    DITTRICH, P
    KANDLER, O
    ZEITSCHRIFT FUR PFLANZENPHYSIOLOGIE, 1972, 66 (04): : 368 - &
  • [40] Relationship between PCBs in blood and D-glucaric acid in urine
    Apostoli, P
    Mangili, A
    Carasi, S
    Manno, M
    TOXICOLOGY LETTERS, 2003, 144 (01) : 17 - 26