Display of Peptides on the Surface of Tobacco Mosaic Virus Particles

被引：0

作者：

Smith, M. L. ^{[2
]}

Fitzmaurice, W. P. ^{[3
]}

Turpen, T. H. ^{[4
]}

Palmer, K. E. ^{[1
]}

机构：

[1] Univ Louisville, Owensboro Canc Res Program, Owensboro, KY 42303 USA

[2] Large Scale Biol Corp, Vacaville, CA 95688 USA

[3] Novici Biotech, Vacaville, CA 95688 USA

[4] Technol Innovat Grp Inc, Austin, TX 78750 USA

来源：

PLANT-PRODUCED MICROBIAL VACCINES | 2009年 / 332卷

关键词：

tobacco mosaic virus; vaccine; plant; virus-like particle; papillomavirus; MALARIA VACCINE; EPITOPES; PROTEIN; IMMUNOGENICITY; INACTIVATION; PURIFICATION; PROTECTION; EXPRESSION; RESPONSES; ANTIGEN;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this review, we focus on the potential that tobacco mosaic virus (TMV) has as a carrier for immunogenic epitopes, and the factors that must be considered in order to bring products based on this platform to the market. Large Scale Biology Corporation developed facile and scaleable methods for manufacture of candidate peptide display vaccines based on TMV. We describe how rational design of., peptide vaccines can improve the manufacturability of particular TMV products. We also discuss downstream processing and purification of the vaccine products, with particular attention to the metrics that a product must attain in order to meet criteria for regulatory approval as injectable biologics.

引用

页码：13 / 31

页数：19

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