Bacterial populations as perfect gases:: genomic integrity and diversification tensions in Helicobacter pylori

被引：86

作者：

Kang, Josephine ^{[1
]}

Blaser, Martin J.

机构：

[1] NYU, Sch Med, Dept Med, New York, NY 10016 USA

[2] NYU, Sch Med, Dept Microbiol, New York, NY 10016 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2006年 / 4卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrmicro1528

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Microorganisms that persist in single hosts face particular challenges. Helicobacter pylori, an obligate bacterial parasite of the human stomach, has evolved a lifestyle that features interstrain competition and intraspecies cooperation, both of which involve horizontal gene transfer. Microbial species must maintain genomic integrity, yet H. pylori has evolved a complex nonlinear system for diversification that exists in dynamic tension with the mechanisms for ensuring fidelity. Here, we review these tensions and propose that they create a dynamic pool of genetic variants that is sufficiently genetically diverse to allow H. pylori to occupy all of the potential niches in the stomach.

引用

收藏

页码：826 / 836

页数：11

相关论文

共 98 条

[1] MUTAGENESIS AND DNA-REPAIR FOR ALKYLATION DAMAGES IN ESCHERICHIA-COLI K-12 [J].

ABRIL, N ;

ROLDANARJONA, T ;

PRIETOALAMO, MJ ;

VANZEELAND, AA ;

PUEYO, C .

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1992, 19 (04) :288-296

[2] Recombination and clonal groupings within Helicobacter pylori from different geographical regions [J].

Achtman, M ;

Azuma, T ;

Berg, DE ;

Ito, Y ;

Morelli, G ;

Pan, ZJ ;

Suerbaum, S ;

Thompson, SA ;

van der Ende, A ;

van Doorn, LJ .

MOLECULAR MICROBIOLOGY, 1999, 32 (03) :459-470

[3] DNA DIVERSITY AMONG CLINICAL ISOLATES OF HELICOBACTER-PYLORI DETECTED BY PCR-BASED RAPD FINGERPRINTING [J].

AKOPYANZ, N ;

BUKANOV, NO ;

WESTBLOM, TU ;

KRESOVICH, S ;

BERG, DE .

NUCLEIC ACIDS RESEARCH, 1992, 20 (19) :5137-5142

[4] PCR-BASED RFLP ANALYSIS OF DNA-SEQUENCE DIVERSITY IN THE GASTRIC PATHOGEN HELICOBACTER-PYLORI [J].

AKOPYANZ, N ;

BUKANOV, N ;

WESTBLOM, TU ;

BERG, DE .

NUCLEIC ACIDS RESEARCH, 1992, 20 (23) :6221-6225

[5] Analysis of the genetic diversity of Helicobacter pylori:: the tale of two genomes [J].

Alm, RA ;

Trust, TJ .

JOURNAL OF MOLECULAR MEDICINE-JMM, 1999, 77 (12) :834-846

[6] Restriction-modification system differences in Helicobacter pylori are a barrier to interstrain plasmid transfer [J].

Ando, T ;

Xu, Q ;

Torres, M ;

Kusugami, K ;

Israel, DA ;

Blaser, MJ .

MOLECULAR MICROBIOLOGY, 2000, 37 (05) :1052-1065

[7] Extensive repetitive DNA facilitates prokaryotic genome plasticity [J].

Aras, RA ;

Kang, J ;

Tschumi, AI ;

Harasaki, Y ;

Blaser, MJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (23) :13579-13584

[8] Helicobacter pylori interstrain restriction-modification diversity prevents genome subversion by chromosomal DNA from competing strains [J].

Aras, RA ;

Small, AJ ;

Ando, T ;

Blaser, MJ .

NUCLEIC ACIDS RESEARCH, 2002, 30 (24) :5391-5397

[9] Regulation of the HpyII restriction-modification system of Helicobacter pylori by gene deletion and horizontal reconstitution [J].

Aras, RA ;

Takata, T ;

Ando, T ;

van der Ende, A ;

Blaser, MJ .

MOLECULAR MICROBIOLOGY, 2001, 42 (02) :369-382

[10] MOSAICISM IN VACUOLATING CYTOTOXIN ALLELES OF HELICOBACTER-PYLORI - ASSOCIATION OF SPECIFIC VACA TYPES WITH CYTOTOXIN PRODUCTION AND PEPTIC-ULCERATION [J].

ATHERTON, JC ;

CAO, P ;

PEEK, RM ;

TUMMURU, MKR ;

BLASER, MJ ;

COVER, TL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (30) :17771-17777

← 1 2 3 4 5 6 7 8 9 10 →