Bacterial populations as perfect gases:: genomic integrity and diversification tensions in Helicobacter pylori

被引:86
作者
Kang, Josephine [1 ]
Blaser, Martin J.
机构
[1] NYU, Sch Med, Dept Med, New York, NY 10016 USA
[2] NYU, Sch Med, Dept Microbiol, New York, NY 10016 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1038/nrmicro1528
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Microorganisms that persist in single hosts face particular challenges. Helicobacter pylori, an obligate bacterial parasite of the human stomach, has evolved a lifestyle that features interstrain competition and intraspecies cooperation, both of which involve horizontal gene transfer. Microbial species must maintain genomic integrity, yet H. pylori has evolved a complex nonlinear system for diversification that exists in dynamic tension with the mechanisms for ensuring fidelity. Here, we review these tensions and propose that they create a dynamic pool of genetic variants that is sufficiently genetically diverse to allow H. pylori to occupy all of the potential niches in the stomach.
引用
收藏
页码:826 / 836
页数:11
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