Efficient microwave-assisted synthesis of highly functionalized pyrimidine derivatives

被引：44
|
作者：
Hartung, Christian G. [1 ]
Backes, Alexander C. [1 ]
Felber, Beatrice [1 ]
Missio, Andrea [1 ]
Philipp, Alexander [1 ]
机构：
[1] GPC Biotech AG, D-82152 Martinsried, Germany
来源：
TETRAHEDRON | 2006年 / 62卷 / 43期
关键词：
D O I：
10.1016/j.tet.2006.08.065
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A generally applicable one-pot procedure for the rapid, easy, and diverse asymmetric functionalization of pyrimidines was developed that requires minimum efforts for the purification of the final products. 4-Amino-6-aryl-substituted pyrimidines are prepared in good yields by combined microwave-assisted amination and Suzuki-Miyaura cross-coupling reactions. The acid-mediated animation reaction affords the products as easily separable salts in 30-40 min reaction time. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：10055 / 10064
页数：10
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