Efficient microwave-assisted synthesis of highly functionalized pyrimidine derivatives

被引：43

作者：

Hartung, Christian G. ^{[1
]}

Backes, Alexander C. ^{[1
]}

Felber, Beatrice ^{[1
]}

Missio, Andrea ^{[1
]}

Philipp, Alexander ^{[1
]}

机构：

[1] GPC Biotech AG, D-82152 Martinsried, Germany

来源：

TETRAHEDRON | 2006年 / 62卷 / 43期

关键词：

D O I：

10.1016/j.tet.2006.08.065

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A generally applicable one-pot procedure for the rapid, easy, and diverse asymmetric functionalization of pyrimidines was developed that requires minimum efforts for the purification of the final products. 4-Amino-6-aryl-substituted pyrimidines are prepared in good yields by combined microwave-assisted amination and Suzuki-Miyaura cross-coupling reactions. The acid-mediated animation reaction affords the products as easily separable salts in 30-40 min reaction time. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：10055 / 10064

页数：10

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