One-pot three-component regioselective synthesis of C1-functionalised 3-arylbenzo[f]quinoline

An efficient method for regioselective synthesis of C1-functionalised 3-arylbenzo[f]quinoline has been demonstrated via gamma-selective aromatization using beta-ketoester, 2-naphthylamine and aromatic aldehyde by employing 10 mol% camphorsulfonic acid as the catalyst in acetonitrile at 70 degrees C. In this approach, two C-C bond formations will result in functionalised benzo[f]quinoline in a one-pot three-component reaction. In addition, the present protocol has a diverse substrate scope with good yields. Furthermore, the protocol was directly utilised for the synthesis of alkyl 2-(3-(naphthalen-2-yl)benzo[f]quinolin-1-yl) acetate, allyl 2-(3-(heteroaromatic) benzo[f]quinolin-1-yl) acetate and functionalised 1,2,3-trisubstituted benzo[f]quinoline.