MicroRNAs (miRNAs) are a class of 22-25 nucleotide RNAs that control gene expression at the post-transcriptional level. MiRNAs have potential as cancer biomarkers. Melanoma is a highly aggressive form of skin cancer accounting for almost 4% of cancers among men and women, and similar to 80% of skin cancer-related deaths in the US. In the present study we analyzed plasma-derived exosomal miRNAs from clinically affected and unaffected familial melanoma patients (CDKN2A/p16 gene carriers) and compared them with affected (nonfamilial melanoma) and unaffected control subjects in order to identify novel risk biomarkers for melanoma. Intact miRNAs can be isolated from the circulation because of their presence in exosomes. A number of differentially regulated miRNAs identified by NanoString human V2 miRNA array were validated by quantitative PCR. Significantly, miR-17, miR-19a, miR-21, miR-126, and miR-149 were expressed at higher levels in patients with metastatic sporadic melanoma as compared with familial melanoma patients or unaffected control subjects. Surprisingly, no substantial differences in miRNA expression were detected between familial melanoma patients (all inclusive) and unaffected control subjects. The miRNAs differentially expressed in the different patient cohorts, especially in patients with metastatic melanoma, may play important roles in tumor progression and metastasis, and may be used as predictive biomarkers to monitor remission as well as relapse following therapeutic intervention.
机构:
QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia
Univ Queensland, Brisbane, Qld, AustraliaQIMR Berghofer Med Res Inst, Brisbane, Qld, Australia
Aoude, Lauren G.
;
Wadt, Karin A. W.
论文数: 0引用数: 0
h-index: 0
机构:
Rigshosp, Dept Clin Genet, DK-2100 Copenhagen, DenmarkQIMR Berghofer Med Res Inst, Brisbane, Qld, Australia
Wadt, Karin A. W.
;
Pritchard, Antonia L.
论文数: 0引用数: 0
h-index: 0
机构:
QIMR Berghofer Med Res Inst, Brisbane, Qld, AustraliaQIMR Berghofer Med Res Inst, Brisbane, Qld, Australia
Pritchard, Antonia L.
;
Hayward, Nicholas K.
论文数: 0引用数: 0
h-index: 0
机构:
QIMR Berghofer Med Res Inst, Brisbane, Qld, AustraliaQIMR Berghofer Med Res Inst, Brisbane, Qld, Australia
机构:
Karolinska Univ, Karolinska Inst, Dept Mol Med & Surg, SE-17176 Stockholm, SwedenKarolinska Univ, Karolinska Inst, Dept Mol Med & Surg, SE-17176 Stockholm, Sweden
Caramuta, Stefano
;
Egyhazi, Suzanne
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Oncol Pathol, Stockholm, SwedenKarolinska Univ, Karolinska Inst, Dept Mol Med & Surg, SE-17176 Stockholm, Sweden
Egyhazi, Suzanne
;
Rodolfo, Monica
论文数: 0引用数: 0
h-index: 0
机构:
Ist Nazl Tumori, Dept Expt Oncol, I-20133 Milan, ItalyKarolinska Univ, Karolinska Inst, Dept Mol Med & Surg, SE-17176 Stockholm, Sweden
Rodolfo, Monica
;
Witten, Daniela
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Stat, Stanford, CA 94305 USAKarolinska Univ, Karolinska Inst, Dept Mol Med & Surg, SE-17176 Stockholm, Sweden
Witten, Daniela
;
Hansson, Johan
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Oncol Pathol, Stockholm, SwedenKarolinska Univ, Karolinska Inst, Dept Mol Med & Surg, SE-17176 Stockholm, Sweden
Hansson, Johan
;
Larsson, Catharina
论文数: 0引用数: 0
h-index: 0
机构:Karolinska Univ, Karolinska Inst, Dept Mol Med & Surg, SE-17176 Stockholm, Sweden
Larsson, Catharina
;
Lui, Weng-Onn
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Univ, Karolinska Inst, Dept Mol Med & Surg, SE-17176 Stockholm, SwedenKarolinska Univ, Karolinska Inst, Dept Mol Med & Surg, SE-17176 Stockholm, Sweden
机构:
Queen Elizabeth Hosp, Dept Clin Oncol, Kowloon, Hong Kong, Peoples R ChinaQueen Elizabeth Hosp, Dept Clin Oncol, Kowloon, Hong Kong, Peoples R China
机构:
Nagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, JapanNagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, Japan
Ebi, H.
;
Sato, T.
论文数: 0引用数: 0
h-index: 0
机构:
Nagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, JapanNagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, Japan
Sato, T.
;
Sugito, N.
论文数: 0引用数: 0
h-index: 0
机构:
Nagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, JapanNagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, Japan
Sugito, N.
;
Hosono, Y.
论文数: 0引用数: 0
h-index: 0
机构:
Nagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, JapanNagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, Japan
Hosono, Y.
;
Yatabe, Y.
论文数: 0引用数: 0
h-index: 0
机构:
Aichi Canc Ctr Hosp, Dept Pathol & Mol Diag, Showa Ku, Nagoya, Aichi 464, JapanNagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, Japan
Yatabe, Y.
;
Matsuyama, Y.
论文数: 0引用数: 0
h-index: 0
机构:
Nagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, JapanNagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, Japan
Matsuyama, Y.
;
论文数: 引用数:
h-index:
机构:
Yamaguchi, T.
;
Osada, H.
论文数: 0引用数: 0
h-index: 0
机构:
Aichi Canc Ctr, Res Inst, Div Mol Oncol, Showa Ku, Nagoya, Aichi 464, JapanNagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, Japan
Osada, H.
;
Suzuki, M.
论文数: 0引用数: 0
h-index: 0
机构:
Nagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, JapanNagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, Japan
Suzuki, M.
;
Takahashi, T.
论文数: 0引用数: 0
h-index: 0
机构:
Nagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, JapanNagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, Japan
机构:
Univ Utah, Melanoma & Cutaneous Oncol Program, Huntsman Canc Inst, Salt Lake City, UT USA
Univ Utah, Dept Dermatol, Salt Lake City, UT USAUniv Tennessee, Ctr Hlth Sci, Dept Pathol & Lab Med, Memphis, TN 38163 USA
Cassidy, Pamela
;
Leachman, Sancy
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Melanoma & Cutaneous Oncol Program, Huntsman Canc Inst, Salt Lake City, UT USA
Univ Utah, Dept Dermatol, Salt Lake City, UT USAUniv Tennessee, Ctr Hlth Sci, Dept Pathol & Lab Med, Memphis, TN 38163 USA
机构:
QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia
Univ Queensland, Brisbane, Qld, AustraliaQIMR Berghofer Med Res Inst, Brisbane, Qld, Australia
Aoude, Lauren G.
;
Wadt, Karin A. W.
论文数: 0引用数: 0
h-index: 0
机构:
Rigshosp, Dept Clin Genet, DK-2100 Copenhagen, DenmarkQIMR Berghofer Med Res Inst, Brisbane, Qld, Australia
Wadt, Karin A. W.
;
Pritchard, Antonia L.
论文数: 0引用数: 0
h-index: 0
机构:
QIMR Berghofer Med Res Inst, Brisbane, Qld, AustraliaQIMR Berghofer Med Res Inst, Brisbane, Qld, Australia
Pritchard, Antonia L.
;
Hayward, Nicholas K.
论文数: 0引用数: 0
h-index: 0
机构:
QIMR Berghofer Med Res Inst, Brisbane, Qld, AustraliaQIMR Berghofer Med Res Inst, Brisbane, Qld, Australia
机构:
Karolinska Univ, Karolinska Inst, Dept Mol Med & Surg, SE-17176 Stockholm, SwedenKarolinska Univ, Karolinska Inst, Dept Mol Med & Surg, SE-17176 Stockholm, Sweden
Caramuta, Stefano
;
Egyhazi, Suzanne
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Oncol Pathol, Stockholm, SwedenKarolinska Univ, Karolinska Inst, Dept Mol Med & Surg, SE-17176 Stockholm, Sweden
Egyhazi, Suzanne
;
Rodolfo, Monica
论文数: 0引用数: 0
h-index: 0
机构:
Ist Nazl Tumori, Dept Expt Oncol, I-20133 Milan, ItalyKarolinska Univ, Karolinska Inst, Dept Mol Med & Surg, SE-17176 Stockholm, Sweden
Rodolfo, Monica
;
Witten, Daniela
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Stat, Stanford, CA 94305 USAKarolinska Univ, Karolinska Inst, Dept Mol Med & Surg, SE-17176 Stockholm, Sweden
Witten, Daniela
;
Hansson, Johan
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Oncol Pathol, Stockholm, SwedenKarolinska Univ, Karolinska Inst, Dept Mol Med & Surg, SE-17176 Stockholm, Sweden
Hansson, Johan
;
Larsson, Catharina
论文数: 0引用数: 0
h-index: 0
机构:Karolinska Univ, Karolinska Inst, Dept Mol Med & Surg, SE-17176 Stockholm, Sweden
Larsson, Catharina
;
Lui, Weng-Onn
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Univ, Karolinska Inst, Dept Mol Med & Surg, SE-17176 Stockholm, SwedenKarolinska Univ, Karolinska Inst, Dept Mol Med & Surg, SE-17176 Stockholm, Sweden
机构:
Queen Elizabeth Hosp, Dept Clin Oncol, Kowloon, Hong Kong, Peoples R ChinaQueen Elizabeth Hosp, Dept Clin Oncol, Kowloon, Hong Kong, Peoples R China
机构:
Nagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, JapanNagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, Japan
Ebi, H.
;
Sato, T.
论文数: 0引用数: 0
h-index: 0
机构:
Nagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, JapanNagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, Japan
Sato, T.
;
Sugito, N.
论文数: 0引用数: 0
h-index: 0
机构:
Nagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, JapanNagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, Japan
Sugito, N.
;
Hosono, Y.
论文数: 0引用数: 0
h-index: 0
机构:
Nagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, JapanNagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, Japan
Hosono, Y.
;
Yatabe, Y.
论文数: 0引用数: 0
h-index: 0
机构:
Aichi Canc Ctr Hosp, Dept Pathol & Mol Diag, Showa Ku, Nagoya, Aichi 464, JapanNagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, Japan
Yatabe, Y.
;
Matsuyama, Y.
论文数: 0引用数: 0
h-index: 0
机构:
Nagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, JapanNagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, Japan
Matsuyama, Y.
;
论文数: 引用数:
h-index:
机构:
Yamaguchi, T.
;
Osada, H.
论文数: 0引用数: 0
h-index: 0
机构:
Aichi Canc Ctr, Res Inst, Div Mol Oncol, Showa Ku, Nagoya, Aichi 464, JapanNagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, Japan
Osada, H.
;
Suzuki, M.
论文数: 0引用数: 0
h-index: 0
机构:
Nagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, JapanNagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, Japan
Suzuki, M.
;
Takahashi, T.
论文数: 0引用数: 0
h-index: 0
机构:
Nagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, JapanNagoya Univ, Grad Sch Med, Div Mol Carcinogenesis, Ctr Neurol Dis & Canc,Showa Ku, Nagoya, Aichi 4668550, Japan
机构:
Univ Utah, Melanoma & Cutaneous Oncol Program, Huntsman Canc Inst, Salt Lake City, UT USA
Univ Utah, Dept Dermatol, Salt Lake City, UT USAUniv Tennessee, Ctr Hlth Sci, Dept Pathol & Lab Med, Memphis, TN 38163 USA
Cassidy, Pamela
;
Leachman, Sancy
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Melanoma & Cutaneous Oncol Program, Huntsman Canc Inst, Salt Lake City, UT USA
Univ Utah, Dept Dermatol, Salt Lake City, UT USAUniv Tennessee, Ctr Hlth Sci, Dept Pathol & Lab Med, Memphis, TN 38163 USA