Analgesic Effects Evoked by Real and Imagined Acupuncture: A Neuroimaging Study

被引:36
作者
Cao, Jin [1 ,2 ]
Tu, Yiheng [1 ]
Orr, Scott P. [1 ]
Lang, Courtney [1 ]
Park, Joel [1 ]
Vangel, Mark [3 ]
Chen, Lucy [4 ]
Gollub, Randy [1 ,5 ]
Kong, Jian [1 ,5 ]
机构
[1] Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Charlestown, MA 02129 USA
[2] Beijing Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Beijing 100029, Peoples R China
[3] Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Charlestown, MA 02129 USA
[4] Harvard Med Sch, Massachusetts Gen Hosp, Dept Anesthesia, Charlestown, MA 02129 USA
[5] Harvard Med Sch, Massachusetts Gen Hosp, Martinos Brain Imaging Ctr, Charlestown, MA 02129 USA
基金
美国国家卫生研究院;
关键词
acupuncture analgesia; chronic pain; fMRI; imagery; video-guided acupuncture imagery treatment; LOW-BACK-PAIN; PLACEBO ANALGESIA; BRAIN ACTIVITY; ELECTRICAL-STIMULATION; NEURAL MECHANISMS; MOTOR CORTEX; FMRI; PERCEPTION; ACTIVATION; EMPATHY;
D O I
10.1093/cercor/bhy190
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Acupuncture can provide therapeutic analgesic benefits but is limited by its cost and scheduling difficulties. Guided imagery is a commonly used method for treating many disorders, such as chronic pain. The present study examined a novel intervention for pain relief that integrates acupuncture with imagery called video-guided acupuncture imagery treatment (VGAIT). A total of 27 healthy subjects were recruited for a crossover-design study that included 5 sessions administered in a randomized order (i.e., baseline and 4 different interventions). We investigated changes in pain threshold and fMRI signals modulated by: 1) VGAIT, watching a video of acupuncture previously administered on the participant's own body at baseline while imagining it being concurrently applied; 2) a VGAIT control condition, watching a video of a cotton swab touching the skin; 3) real acupuncture; and 4) sham acupuncture. Results demonstrated that real acupuncture and VGAIT significantly increased pain threshold compared with respective control groups. Imaging showed that real acupuncture produced greater activation of the insula compared with VGAIT. VGAIT produced greater deactivation at the rostral anterior cingulate cortex. Our findings demonstrate that VGAIT holds potential clinical value for pain management.
引用
收藏
页码:3220 / 3231
页数:12
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