Autophagy and the immune function in aging

被引：82

作者：

Cuervo, Ana Maria ^{[1
,3
]}

Macian, Fernando ^{[2
,3
]}

机构：

[1] Albert Einstein Coll Med, Dept Dev & Mol Biol, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10461 USA

[3] Albert Einstein Coll Med, Inst Aging Studies, Bronx, NY 10461 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2014年 / 29卷

基金：

美国国家卫生研究院;

关键词：

CHAPERONE-MEDIATED AUTOPHAGY; MHC CLASS-II; OXIDATIVE STRESS; GENE ATG5; CELLS; INFLAMMASOME; ACTIVATION; MACROAUTOPHAGY; KINASE; MICROAUTOPHAGY;

D O I：

10.1016/j.coi.2014.05.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Just when you thought that you had heard it all about autophagy the conserved cellular process that mediates turnover of cellular constituents in the lysosomes studies keep coming out highlighting new types of autophagy, new functions for autophagy or even new autophagy-independent roles for the proteins associated with this process. The field of immunology has been riding the autophagic wave since the beginning of its revival; first due to its role in the host defense against pathogens, and more recently through the better understanding of the unique characteristics and functions of different autophagic pathways in immune cells. Here, we describe some of these new functions that are tightening the connection between autophagy and acquired or innate immunity and their malfunctioning with age.

引用

页码：97 / 104

页数：8

共 62 条

[1] Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance [J].

Aichinger, Martin ;

Wu, Chunyan ;

Nedjic, Jelena ;

Klein, Ludger .

JOURNAL OF EXPERIMENTAL MEDICINE, 2013, 210 (02) :287-300

[2] Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance [J].

Arndt, Verena ;

Dick, Nikolaus ;

Tawo, Riga ;

Dreiseidler, Michael ;

Wenzel, Daniela ;

Hesse, Michael ;

Fuerst, Dieter O. ;

Saftig, Paul ;

Saint, Robert ;

Fleischmann, Bernd K. ;

Hoch, Michael ;

Hoehfeld, Joerg .

CURRENT BIOLOGY, 2010, 20 (02) :143-148

[3] Autophagy Regulates Phagocytosis by Modulating the Expression of Scavenger Receptors [J].

Bonilla, Diana L. ;

Bhattacharya, Abhisek ;

Sha, Youbao ;

Xu, Yi ;

Xiang, Qian ;

Kan, Arshad ;

Jagannath, Chinnaswamy ;

Komatsu, Masaaki ;

Eissa, N. Tony .

IMMUNITY, 2013, 39 (03) :537-547

[4] A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells [J].

Cadwell, Ken ;

Liu, John Y. ;

Brown, Sarah L. ;

Miyoshi, Hiroyuki ;

Loh, Joy ;

Lennerz, Jochen K. ;

Kishi, Chieko ;

Kc, Wumesh ;

Carrero, Javier A. ;

Hunt, Steven ;

Stone, Christian D. ;

Brunt, Elizabeth M. ;

Xavier, Ramnik J. ;

Sleckman, Barry P. ;

Li, Ellen ;

Mizushima, Noboru ;

Stappenbeck, Thaddeus S. ;

Virgin, Herbert W. .

NATURE, 2008, 456 (7219) :259-U62

[5] Age-Related Oxidative Stress Compromises Endosomal Proteostasis [J].

Cannizzo, Elvira S. ;

Clement, Cristina C. ;

Morozova, Kateryna ;

Valdor, Rut ;

Kaushik, Susmita ;

Almeida, Larissa N. ;

Follo, Carlo ;

Sahu, Ranjit ;

Cuervo, Ana Maria ;

Macian, Fernando ;

Santambrogio, Laura .

CELL REPORTS, 2012, 2 (01) :136-149

[6] Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation [J].

Castillo, Eliseo F. ;

Dekonenko, Alexander ;

Arko-Mensah, John ;

Mandell, Michael A. ;

Dupont, Nicolas ;

Jiang, Shanya ;

Delgado-Vargas, Monica ;

Timmins, Graham S. ;

Bhattacharya, Dhruva ;

Yang, Hongliang ;

Hutt, Julie ;

Lyons, C. Rick ;

Dobos, Karen M. ;

Deretic, Vojo .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (46) :E3168-E3176

[7] Beclin 1-independent pathway of damage-induced mitophagy and autophagic stress [J].

Chu, Charleen T. ;

Zhu, Jianhui ;

Dagda, Ruben .

AUTOPHAGY, 2007, 3 (06) :663-666

[8] Canonical and non-canonical autophagy: variations on a common theme of self-eating? [J].

Codogno, Patrice ;

Mehrpour, Maryam ;

Proikas-Cezanne, Tassula .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2012, 13 (01) :7-12

[9] NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation [J].

Cooney, Rachel ;

Baker, John ;

Brain, Oliver ;

Danis, Benedicte ;

Pichulik, Tica ;

Allan, Philip ;

Ferguson, David J. P. ;

Campbell, Barry J. ;

Jewell, Derek ;

Simmons, Alison .

NATURE MEDICINE, 2010, 16 (01) :90-U128

[10] Age-related decline in chaperone-mediated autophagy [J].

Cuervo, AM ;

Dice, JF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (40) :31505-31513

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