Prognostic significance of ARL9 and its methylation in low-grade glioma

被引：38

作者：

Tan, Yutang ^{[1
]}

Zhang, Suojun ^{[1
]}

Xiao, Qungen ^{[1
]}

Wang, Junwen ^{[1
]}

Zhao, Kai ^{[1
]}

Liu, Weihua ^{[1
]}

Huang, Kuan ^{[1
]}

Tian, Weidong ^{[1
,2
]}

Niu, Hongquan ^{[1
]}

Lei, Ting ^{[1
]}

Shu, Kai ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Neurosurg, Wuhan 430030, Peoples R China

[2] Shihezi Univ, Med Coll, Affiliated Hosp 1, Dept Neurosurg, Xinjiang 832000, Peoples R China

来源：

GENOMICS | 2020年 / 112卷 / 06期

关键词：

Low-grade glioma; ARL9; Methylation; Survival; Immune cells; GENOMIC ANALYSIS; BRAIN; SURVIVAL;

D O I：

10.1016/j.ygeno.2020.08.035

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

This study aimed to determine the value of ARL9 expression or methylation as a biomarker for LGG survival. We investigated the expression, methylation, prognosis and immune significance of ARL9 through bioinformatics analysis. ARL9 is negatively regulated by ARL9 methylation, leading to its low expression in LGG tissues. Both low ARL9 expression and hypermethylation predicted favorable OS and PFS in LGG patients, according to the TCGA database. Cox regression demonstrated that low ARL9 expression and ARL9 hypermethylation were independent biomarkers for OS. Moreover, three other glioma databases were utilized to verify the prognostic role of ARL9 in LGG, and the similar results were reached. A meta-analysis revealed that low ARL9 expression was closely relevant to better OS. Finally, ARL9 expression exhibited a close correlation with some immune cells, especially CD8+ T cells. ARL9 could constitute a promising prognostic biomarker, and probably plays an important role in immune cell infiltration in LGG.

引用

页码：4808 / 4816

页数：9

共 33 条

[1] Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas [J].

Brat, Daniel J. ;

Verhaak, Roel G. W. ;

Al-dape, Kenneth D. ;

Yung, W. K. Alfred ;

Salama, Sofie R. ;

Cooper, Lee A. D. ;

Rheinbay, Esther ;

Miller, C. Ryan ;

Vitucci, Mark ;

Morozova, Olena ;

Robertson, A. Gordon ;

Noushmehr, Houtan ;

Laird, Peter W. ;

Cherniack, Andrew D. ;

Akbani, Rehan ;

Huse, Jason T. ;

Ciriello, Giovanni ;

Poisson, Laila M. ;

Barnholtz-Sloan, Jill S. ;

Berger, Mitchel S. ;

Brennan, Cameron ;

Colen, Rivka R. ;

Colman, Howard ;

Flanders, Adam E. ;

Giannini, Caterina ;

Grifford, Mia ;

Iavarone, Antonio ;

Jain, Rajan ;

Joseph, Isaac ;

Kim, Jaegil ;

Kasaian, Katayoon ;

Mikkelsen, Tom ;

Murray, Bradley A. ;

O'Neill, Brian Patrick ;

Pachter, Lior ;

Parsons, Donald W. ;

Sougnez, Carrie ;

Sulman, Erik P. ;

Vandenberg, Scott R. ;

Van Meir, Erwin G. ;

von Deimling, Andreas ;

Zhang, Hailei ;

Crain, Daniel ;

Lau, Kevin ;

Mallery, David ;

Morris, Scott ;

Paulauskis, Joseph ;

Penny, Robert ;

Shelton, Troy ;

Sherman, Mark .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (26) :2481-2498

[2] Gene expression markers of Tumor Infiltrating Leukocytes [J].

Danaher, Patrick ;

Warren, Sarah ;

Dennis, Lucas ;

D'Amico, Leonard ;

White, Andrew ;

Disis, Mary L. ;

Geller, Melissa A. ;

Odunsi, Kunle ;

Beechem, Joseph ;

Fling, Steven P. .

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2017, 5

[3] Profiles of immune-related genes and immune cell infiltration in the tumor microenvironment of diffuse lower-grade gliomas [J].

Deng, Xiangyang ;

Lin, Dongdong ;

Zhang, Xiaojia ;

Shen, Xuchao ;

Yang, Zelin ;

Yang, Liang ;

Lu, Xiangqi ;

Yu, Lisheng ;

Zhang, Nu ;

Lin, Jian .

JOURNAL OF CELLULAR PHYSIOLOGY, 2020, 235 (10) :7321-7331

[4] Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal [J].

Gao, Jianjiong ;

Aksoy, Buelent Arman ;

Dogrusoz, Ugur ;

Dresdner, Gideon ;

Gross, Benjamin ;

Sumer, S. Onur ;

Sun, Yichao ;

Jacobsen, Anders ;

Sinha, Rileen ;

Larsson, Erik ;

Cerami, Ethan ;

Sander, Chris ;

Schultz, Nikolaus .

SCIENCE SIGNALING, 2013, 6 (269) :pl1

[5] Midkine activation of CD8+ T cells establishes a neuron-immune-cancer axis responsible for low-grade glioma growth [J].

Guo, Xiaofan ;

Pan, Yuan ;

Xiong, Min ;

Sanapala, Shilpa ;

Anastasaki, Corina ;

Cobb, Olivia ;

Dahiya, Sonika ;

Gutmann, David H. .

NATURE COMMUNICATIONS, 2020, 11 (01)

[6] Genetic and genomic alterations differentially dictate low-grade glioma growth through cancer stem cell-specific chemokine recruitment of T cells and microglia [J].

Guo, Xiaofan ;

Pan, Yuan ;

Gutmann, David H. .

NEURO-ONCOLOGY, 2019, 21 (10) :1250-1262

[7] Tumour-infiltrating CD4+ and CD8+ lymphocytes as predictors of clinical outcome in glioma [J].

Han, S. ;

Zhang, C. ;

Li, Q. ;

Dong, J. ;

Liu, Y. ;

Huang, Y. ;

Jiang, T. ;

Wu, A. .

BRITISH JOURNAL OF CANCER, 2014, 110 (10) :2560-2568

[8] Genomic analysis of the origins and evolution of multicentric diffuse lower-grade gliomas [J].

Hayes, Josie ;

Yu, Yao ;

Jalbert, Llewellyn E. ;

Mazor, Tali ;

Jones, Lindsey E. ;

Wood, Matthew D. ;

Walsh, Kyle M. ;

Bengtsson, Henrik ;

Hong, Chibo ;

Oberndorfer, Stefan ;

Roetzer, Thomas ;

Smirnov, Ivan V. ;

Clarke, Jennifer L. ;

Aghi, Manish K. ;

Chang, Susan M. ;

Nelson, Sarah J. ;

Woehrer, Adelheid ;

Phillips, Joanna J. ;

Solomon, David A. ;

Costello, Joseph F. .

NEURO-ONCOLOGY, 2018, 20 (05) :632-641

[9] Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor [J].

Hu, Huimin ;

Mu, Quanhua ;

Bao, Zhaoshi ;

Chen, Yiyun ;

Liu, Yanwei ;

Chen, Jing ;

Wang, Kuanyu ;

Wang, Zheng ;

Nam, Yoonhee ;

Jiang, Biaobin ;

Sa, Jason K. ;

Cho, Hee-Jin ;

Her, Nam-Gu ;

Zhang, Chuanbao ;

Zhao, Zheng ;

Zhang, Ying ;

Zeng, Fan ;

Wu, Fan ;

Kang, Xun ;

Liu, Yuqing ;

Qian, Zenghui ;

Wang, Zhiliang ;

Huang, Ruoyu ;

Wang, Qiangwei ;

Zhang, Wei ;

Qiu, Xiaoguang ;

Li, Wenbin ;

Nam, Do-Hyun ;

Fan, Xiaolong ;

Wang, Jiguang ;

Jiang, Tao .

CELL, 2018, 175 (06) :1665-+

[10] Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells [J].

Klemm, Florian ;

Maas, Roeltje R. ;

Bowman, Robert L. ;

Kornete, Mara ;

Soukup, Klara ;

Nassiri, Sina ;

Brouland, Jean-Philippe ;

Iacobuzio-Donahue, Christine A. ;

Brennan, Cameron ;

Tabar, Viviane ;

Gutin, Philip H. ;

Daniel, Roy T. ;

Hegi, Monika E. ;

Joyce, Johanna A. .

CELL, 2020, 181 (07) :1643-+

← 1 2 3 4 →