Incorporating Patient Preferences in Noninferiority Trials

被引：25

作者：

Acuna, Sergio A. ^{[1
]}

Chesney, Tyler R. ^{[1
]}

Baxter, Nancy N. ^{[1
,2
]}

机构：

[1] Univ Toronto, Dept Surg, Div Gen Surg, Toronto, ON, Canada

[2] St Michaels Hosp, Dept Surg, Ka Shing Knowledge Inst, Toronto, ON, Canada

来源：

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 2019年 / 322卷 / 04期

关键词：

D O I：

10.1001/jama.2019.7059

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This Viewpoint discusses the selection and interpretation of noninferiority margins (Delta NIs) in noninferiority trials, reviews techniques for eliciting patient preferences for treatment, and calls for using those preferences to select Delta NIs to better achieve patient-centered trade-offs between efficacy loss for nonefficacy gains represented by the margin.

引用

页码：305 / 306

页数：2

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