Safety and Efficacy of Nemolizumab for Atopic Dermatitis With Pruritus: A Systematic Review and Meta-Regression Analysis of Randomized Controlled Trials

被引：14

作者：

Liang, Junqin ^{[1
]}

Hu, Fengxia ^{[1
]}

Dan, Maoli ^{[1
]}

Sang, Yingbing ^{[1
]}

Abulikemu, Kailibinuer ^{[1
]}

Wang, Qian ^{[1
]}

Hong, Yongzhen ^{[1
]}

Kang, Xiaojing ^{[1
]}

机构：

[1] Peoples Hosp Xinjiang Uygur Autonomous Reg, Xinjiang Clin Research Ctr Dermatol Dis, Dept Dermatol & Venereol, Xinjiang Key Lab Dermatol Res XJYS1707, Urumqi, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

关键词：

pruritus; atopic dermatitis (AD); nemolizumab; randomized controlled trial; meta-analysis; INTERLEUKIN-31; RECEPTOR; IL-31; CELLS; ANTIBODY; ITCH;

D O I：

10.3389/fimmu.2022.825312

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

BackgroundNemolizumab is deemed as a promising drug for atopic dermatitis (AD) patients with pruritus. ObjectiveThis study aimed to evaluate the efficacy of nemolizumab in treating patients with AD and the association between the dosage or regimen of nemolizumab with the improvement in clinical indices. Methods and MaterialsPubMed, Embase, and the Cochrane Library were searched for randomized controlled trials (RCTs) published from inception to August 2021. ResultsA total of 14 cohorts of participants from six randomized controlled studies were included in the meta-analysis. Nemolizumab significantly reduced the pruritus VAS (WMD = -18.86, 95% CI: -27.57 to -10.15, p I-2 = 56.2%, p(heterogeneity) = 0.005) and EASI (WMD = -11.76, 95% CI: -20.55 to -2.96, p = 0.009; I-2 = 0%, p(heterogeneity) = 0.978) scores compared with placebo. No significant difference was observed in the occurrence of any AEs (RR = 1.03, 95% CI: 0.93 to 1.13, p = 0.593; I-2 = 0%, p(heterogeneity) = 0.980) between the two groups. The univariate meta-regression showed that both the dosage and study duration had no association with the change of pruritus VAS score. ConclusionNemolizumab presented a promising effect based on the difference in the average change in pruritus VAS and EASI scores compared with placebo. The results indicated its efficacy in relieving pruritus and the severity of AD and improving patients' quality of life.

引用

页数：7