By C-fiber reflex inhibition by electroacupuncture with different intensities applied at homotopic and heterotopic acupoints in rats selectively destructive effects on myelinated and unmyelinated afferent fibers

被引:62
作者
Zhu, B
Xu, WD
Rong, PJ
Ben, H
Gao, XY
机构
[1] Chinese Acad Tradit Chinese Med, Inst Acupuncture, Beijing 100700, Peoples R China
[2] Hebei Coll Trad Chinese Med, Wuhan 430061, Peoples R China
关键词
C-fiber reflex; electroacupuncture; intensity; cobra venom; capsaicin;
D O I
10.1016/j.brainres.2004.03.034
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The aims of this study were to explore the C-fiber reflex inhibition induced by electroacupuncture with different intensities applied at homotopic or heterotopic acupoints, and to determine the influence selectively destroyed myelinated and unmyelinated afferent fibers on the C-fiber reflex inhibition. In the ipsilateral local acupoint, the general behavior of the C-fiber reflex can be depressed by electroacupuncture below the threshold of Adelta-fiber activation. Electroacupuncture stimulation within the intensity of Adelta-fiber activation applied to the ipsilateral limb pretreated with cobra venom did not elicit inhibition of C-fiber reflex in rats with demyelinated sciatic nerve. However, heterotopic electroacupuncture below the threshold of Adelta-fiber activation was totally ineffective. In contralateral heterotopic acupoints, the C-fiber reflex can be depressed only by electroacupuncture with stimulating intensities exceeding thresholds of Adelta and C-fiber activation. Electroacupuncture stimuli applied to capsaicin-pretreated limb in the intensities of threshold of Adelta-fiber and treble thresholds of C-fiber activation produced only a little inhibition of C-fiber reflex. Inhibitory intensity was roughly similar to that induced by the stimulation with intensity for the activation of Adelta-fiber in normal animal. In the spinalized animals transections at T-6 - T-7 segments, regardless of intensities, the homotopic electroacupuncture stimulation only induced moderate depression of C-fiber reflex similar to that of Adelta-fiber activation; whereas, no matter what intensities of application, the inhibitory effects of C-fiber reflex disappeared totally by using heterotopic noxious electroacupuncture in these animals. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:228 / 237
页数:10
相关论文
共 37 条
[1]   ACUPUNCTURE - FROM EMPIRICISM TO SCIENCE - FUNCTIONAL BACKGROUND TO ACUPUNCTURE EFFECTS IN PAIN AND DISEASE [J].
ANDERSSON, S ;
LUNDEBERG, T .
MEDICAL HYPOTHESES, 1995, 45 (03) :271-281
[2]  
ANDERSSON S A, 1975, American Journal of Chinese Medicine, V3, P311, DOI 10.1142/S0192415X75000396
[3]  
Bao H, 1991, Zhen Ci Yan Jiu, V16, P120
[4]   PERIPHERAL AND SPINAL MECHANISMS OF NOCICEPTION [J].
BESSON, JM ;
CHAOUCH, A .
PHYSIOLOGICAL REVIEWS, 1987, 67 (01) :67-186
[5]  
BIRCH S, 1996, ACUPUNCTURE EFFICACY
[6]   THE SPINAL TRANSMISSION OF NOCICEPTIVE INFORMATION - MODULATION BY THE CAUDAL MEDULLA [J].
BOUHASSIRA, D ;
CHITOUR, D ;
VILLANEUVA, L ;
LEBARS, D .
NEUROSCIENCE, 1995, 69 (03) :931-938
[7]  
BOWSHER D, 1990, J R MED ACUPUNCT SOC, V7, P17
[8]   THE DIGASTRIC REFLEX EVOKED BY TOOTH-PULP STIMULATION IN THE CAT AND ITS MODULATION BY STIMULI APPLIED TO THE LIMBS [J].
CADDEN, SW .
BRAIN RESEARCH, 1985, 336 (01) :33-43
[9]   DEPRESSION OF ACTIVITIES OF DORSAL HORN CONVERGENT NEURONS BY PROPRIOSPINAL MECHANISMS TRIGGERED BY NOXIOUS INPUTS - COMPARISON WITH DIFFUSE NOXIOUS INHIBITORY CONTROLS (DNIC) [J].
CADDEN, SW ;
VILLANUEVA, L ;
CHITOUR, D ;
LEBARS, D .
BRAIN RESEARCH, 1983, 275 (01) :1-11
[10]   DIFFUSE NOXIOUS INHIBITORY CONTROLS (DNIC) INVOLVE TRIGEMINOTHALAMIC AND SPINOTHALAMIC NEURONS IN THE RAT [J].
DICKENSON, AH ;
LEBARS, D .
EXPERIMENTAL BRAIN RESEARCH, 1983, 49 (02) :174-180