Prognostic value of intratumoral lymphocyte-to-monocyte ratio and M0 macrophage enrichment in tumor immune microenvironment of melanoma

被引：18

作者：

Jairath, Neil K. ^{[1
]}

Farha, Mark W. ^{[1
]}

Jairath, Ruple ^{[1
]}

Harms, Paul W. ^{[1
,2
]}

Tsoi, Lam C. ^{[3
]}

Tejasvi, Trilokraj ^{[1
]}

机构：

[1] Univ Michigan, Dept Dermatol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Computat Med & Bioinformat, Dept BioStat, Ann Arbor, MI 48109 USA

来源：

MELANOMA MANAGEMENT | 2020年

关键词：

cutaneous melanoma; immunotherapy; lymphocytes; macrophages; monocytes; RNA sequencing; tumor immune microenvironment; LUNG-CANCER EVIDENCE; INFILTRATING LYMPHOCYTES; PREOPERATIVE LYMPHOCYTE; CUTANEOUS MELANOMA; CELL; SURVIVAL; PEMBROLIZUMAB; METASTASIS; CARCINOMA;

D O I：

10.2217/mmt-2020-0019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Skin cutaneous melanoma is characterized by significant heterogeneity in its molecular, genomic and immunologic features. Whole transcriptome RNA sequencing data from The Cancer Genome Atlas of skin cutaneous melanoma (n = 328) was utilized. CIBERSORT was used to identify immune cell type composition, on which unsupervised hierarchical clustering was performed. Analysis of overall survival was performed using Kaplan-Meier estimates and multivariate Cox regression analyses. Membership in the lymphocyte:monocyte(low), monocyte(high) and M0(high) cluster was an independently poor prognostic factor for survival (HR: 3.03; 95% CI: 1.12-8.20; p = 0.029) and correlated with decreased predicted response to immune checkpoint blockade. In conclusion, an M0-macrophage-enriched, lymphocyte-to-monocyte-ratio-low phenotype in the primary melanoma tumor site independently characterizes an aggressive phenotype that may differentially respond to treatment.

引用

页数：13

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