Epidemiology of congenital Chagas disease 6 years after implementation of a public health surveillance system, Catalonia, 2010 to 2015

被引：33

作者：

Basile, Luca ^{[1
,89
]}

Martin-Nalda, Andrea ^{[5
]}

Jane, Mireia ^{[1
,2
,113
]}

Cebollero, Alba ^{[7
]}

Carrascon, Alicia ^{[8
]}

Moreira, Ana ^{[9
]}

Requena-Mendez, Ana ^{[3
,10
]}

Torres Soto, Ana ^{[11
]}

Martin, Andrea ^{[12
]}

Ballester, Anna ^{[13
]}

Bragulat, Anna ^{[14
]}

Soligo, Anna ^{[15
]}

Vilamala Bastarras, Anna ^{[16
]}

Paya, Antoni ^{[17
]}

Soriano-Arandes, Antoni ^{[18
]}

Sorni, Antoni ^{[19
]}

Calvo, Antonia ^{[20
]}

Mur, Antonio ^{[21
]}

Colomer, Assumpta ^{[22
]}

Carral, Begona ^{[23
]}

Trevino, Begona ^{[24
]}

Guarch, Borja ^{[25
]}

Orta, Carles ^{[26
]}

Rodrigo, Carlos ^{[27
]}

Galles, Carme ^{[28
]}

Garrido, Carme ^{[29
]}

Molina, Carme ^{[30
]}

Mora, Carme ^{[31
]}

Munoz, Carmen ^{[32
]}

Marti, Carmina ^{[33
]}

Sanjose, Carmina ^{[34
]}

Guardia, Celia ^{[35
]}

Cortes, Cristina ^{[36
]}

Gutierrez, Cristina ^{[37
]}

Martinez, Cristina ^{[38
]}

Riera, Cristina ^{[39
]}

Soler, Cristina ^{[40
]}

Gonzalez, Dolors ^{[41
]}

Guix, Dolors ^{[42
]}

Sole Mir, Eduard ^{[43
]}

Padilla, Eduardo ^{[44
]}

Sulleiro, Elena ^{[6
,45
]}

Llurba, Elisa ^{[46
]}

Del Amo, Elisabeth ^{[47
]}

Moliner, Elisenda ^{[48
]}

Padilla Esteba, Emma ^{[49
]}

Coll, Engracia ^{[50
]}

Rodriguez, Enrique ^{[51
]}

Monaco, Enrnesto ^{[52
]}

Munoz, Ester ^{[53
]}

机构：

[1] Publ Hlth Agcy Catalonia, Barcelona, Spain

[2] Carlos III Hlth Inst, CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain

[3] Univ Barcelona, Hosp Clin, Barcelona Inst Global Hlth ISGlobal, Barcelona, Spain

[4] Lab Clin LHospitalet, Barcelona, Spain

[5] UAB, VHIR, HUVH, Pediat Infect Dis & Immunodeficiencies Unit, Barcelona, Spain

[6] UAB, HUVH, PROSICS Barcelona, Dept Microbiol, Barcelona, Spain

[7] Consorci Lab Intercomarcal, CLILAB Diagnost, Barcelona, Spain

[8] ICS, ASSIR Izquierdo Barcelona Ciudad, Barcelona, Spain

[9] Hosp St Joan de Deu Martorell, Barcelona, Spain

[10] Univ Barcelona, Hosp Clin Barcelona, ISGlobal, Barcelona, Spain

[11] Hosp Residencia St Camil, Barcelona, Spain

[12] Hosp Univ Vall dHebron, Barcelona, Spain

[13] Corp Salut Maresme & Selva, Barcelona, Spain

[14] Hosp Cerdanya, Puigcerda, Spain

[15] ASSIR Consorci Sanitari Terrassa, Terrassa, Spain

[16] Consorci Hosp Vic, Vic, Spain

[17] Hosp Mar, Barcelona, Spain

[18] Hosp Univ Vall dHebron, Barcelona, Spain

[19] Hosp Verge Cinta Tortosa, Tortosa, Spain

[20] Hosp Clin Barcelona, Barcelona, Spain

[21] Hosp Mar, Barcelona, Spain

[22] Consorci Hosp Vic, Vic, Spain

[23] ICS, ASSIR Baix Llobregat Litoral, Barcelona, Spain

[24] Hosp Univ Vall dHebron, Unitat Salut Int Drassanes, Barcelona, Spain

[25] Hosp Univ Dr Josep Trueta Girona, Girona, Spain

[26] Hosp Comarcal Alt Penedes, Vilafranca Del Penedes, Spain

[27] Hosp Badalona Germans Trias & Pujol, Barcelona, Spain

[28] Corp Salut Maresme & Selva, Calella, Spain

[29] Hosp Santa Creu & Sant Pau, Barcelona, Spain

[30] Hosp Joan XXIII Tarragona, Tarragona, Spain

[31] Hosp Figueres, Figueres, Spain

[32] Hosp Santa Creu & Sant Pau, Barcelona, Spain

[33] Hosp Gen Granollers, Granollers, Spain

[34] Consorcio Lab Intercomarcal, CLILAB Diagnost, Barcelona, Spain

[35] Lab Barcelones Nord & Valles Oriental, Barcelona, Spain

[36] Hosp Gen LHospitalet, Barcelona, Spain

[37] Hosp Univ Joan XXIII Tarragona, Tarragona, Spain

[38] ICS, ASSIR Barcelona Ciutat, Barcelona, Spain

[39] Univ Barcelona, Fac Farm, Barcelona, Spain

[40] Hosp Santa Caterina, Salt, Spain

[41] ICS Camp Tarragona, CAP Rambla Nova, Tarragona, Spain

[42] ICS, ASSIR Granollers, Granollers, Spain

[43] Hosp Arnau Vilanova, IRBLleida, Lleida, Spain

[44] Lab Referencia Catalunya, Catalunya, Spain

[45] Hosp Univ Vall dHebron, Barcelona, Spain

[46] Hosp Santa Creu & Sant Pau, Barcelona, Spain

[47] ICS, ASSIR Litoral Barcelona Ciudad, Barcelona, Spain

[48] Hosp Santa Creu & Sant Pau, Barcelona, Spain

[49] AIE, Ctr Analit Terrassa, Catlab, Viladecavalls, Spain

[50] ASSIR Hosp Mutua Terrassa, ICS, Terrassa, Spain

来源：

EUROSURVEILLANCE | 2019年 / 24卷 / 26期

关键词：

TRYPANOSOMA-CRUZI INFECTION; LATIN-AMERICAN WOMEN; PREGNANT-WOMEN; VERTICAL TRANSMISSION; PEDIATRIC CHAGAS; PREVALENCE; EXPERIENCE; BARCELONA; AREA; DIAGNOSIS;

D O I：

10.2807/1560-7917.ES.2019.24.26.19-00011

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background: Chagas disease is endemic in Latin America and affects 8 million people worldwide. In 2010, Catalonia introduced systematic public health surveillance to detect and treat congenital Chagas disease. Aim: The objective was to evaluate the health outcomes of the congenital Chagas disease screening programme during the first 6 years (2010-2015) after its introduction in Catalonia. Methods: In a surveillance system, we screened pregnant women and newborns and other children of positive mothers, and treated Chagas-positive newborns and children. Diagnosis was confirmed for pregnant women and children with two positive serological tests and for newborns with microhaematocrit and/or PCR at birth or serology at age 9 months. Results: From 2010 to 2015, the estimated screening coverage rate increased from 68.4% to 88.6%. In this period, 33,469 pregnant women were tested for Trypanosoma cruzi and 937 positive cases were diagnosed. The overall prevalence was 2.8 cases per loo pregnancies per year (15.8 in Bolivian women). We followed 82.8% of newborns until serological testing at age 9-12 months and 28 were diagnosed with Chagas disease (congenital transmission rate: 4.17%). Of 518 siblings, 178 (34.3%) were tested and 14 (7.8%) were positive for T. cruzi. Having other children with Chagas disease and the heart clinical form of Chagas disease were maternal risk factors associated with congenital T. cruzi infection (p < 0.05). Conclusion: The increased screening coverage rate indicates consolidation of the programme in Catalonia. The rate of Chagas disease congenital transmission in Catalonia is in accordance with the range in non-endemic countries.

引用

页码：15 / 30

页数：16

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