H7N9: a low pathogenic avian influenza A virus infecting humans

被引：66
作者：
Liu, Jun [1 ]
Xiao, Haixia [2 ]
Wu, Yan [3 ]
Liu, Di [3 ]
Qi, Xiaopeng [4 ]
Shi, Yi [5 ]
Gao, George F. [1 ,3 ,5 ,6 ]
机构：
[1] Chinese Ctr Dis Control & Prevent China CDC, Natl Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China
[2] Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Lab Prot Engn & Vaccines, Tianjin 300308, Peoples R China
[3] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China
[4] Chinese Ctr Dis Control & Prevent, Natl Ctr Publ Hlth Surveillance & Informat Serv, Beijing 102206, Peoples R China
[5] Chinese Acad Sci, Beijing Inst Life Sci, Res Network Immun & Hlth, Beijing 100101, Peoples R China
[6] Chinese Ctr Dis Control & Prevent China CDC, Off Director Gen, Beijing 102206, Peoples R China
来源：
CURRENT OPINION IN VIROLOGY | 2014年 / 5卷
基金：
中国国家自然科学基金;
关键词：
RECEPTOR-BINDING; CONSTRUCTS PROTECT; HEMAGGLUTININ; ORIGIN; MARKETS; VACCINE; CHINA; FEATURES; MICE;
D O I：
10.1016/j.coviro.2014.03.001
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Human infections by the newly reassorted avian influenza A (H7N9) virus were reported for the first time in early 2013, and the virus was confirmed to be a low pathogenic avian influenza virus in poultry. Because continuously reported cases have been increasing since the summer of 2013, this novel virus poses a potential threat to public health in China and is attracting broad attention worldwide. In this review, we summarize and discuss the characteristics of the H7N9 virus revealed by the recent timely studies from the perspectives of epidemiology, host preference, clinical manifestations, immunopathogenesis, drug resistance, vaccine development, and burden of disease. This knowledge about the novel avian-origin H7N9 virus will provide a useful reference for clinical interventions of human infections and help to rapidly pave the way to develop an efficient and safe vaccine.
引用
收藏
页码：91 / 97
页数：7
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