Current concepts in the pathophysiology and treatment of aplastic anemia

被引：155

作者：

Young, Neal S. ^{[1
]}

机构：

[1] NHLBI, Hematol Branch, NIH, Bethesda, MD 20892 USA

来源：

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM | 2013年

关键词：

RABBIT ANTITHYMOCYTE GLOBULIN; IMMUNOSUPPRESSIVE THERAPY; PLUS CYCLOSPORINE; CELLS; MUTATIONS; SURVIVAL;

D O I：

10.1182/asheducation-2013.1.76

中图分类号：

G40 [教育学];

学科分类号：

040101 ; 120403 ;

摘要：

Historically viewed in isolation as an odd, rare, and invariably fatal blood disease, aplastic anemia is now of substantial interest for its immune pathophysiology, its relationship to constitutional BM failure syndromes and leukemia, and the success of both stem cell transplantation and immunosuppressive therapies in dramatically improving survival of patients. Once relegated to a few presentations in the red cell and anemia sessions of the ASH, the Society now sponsors multiple simultaneous sessions and plenary and scientific committee presentations on these topics. This update emphasizes developments in our understanding of immune mechanisms and hematopoietic stem cell biology and new clinical approaches to stem cell stimulation as a therapy, alone and in combination with conventional suppression of the aberrant immune system.

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页码：76 / 81

页数：6

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