Wavelength-Controlled Photocleavage for the Orthogonal and Sequential Release of Multiple Proteins

被引：149
|
作者：
Azagarsamy, Malar A. [1 ,2 ]
Anseth, Kristi S. [1 ,2 ]
机构：
[1] Univ Colorado, Howard Hughes Med Inst, Dept Chem & Biol Engn, Boulder, CO 80303 USA
[2] Univ Colorado, BioFrontiers Inst, Boulder, CO 80303 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 51期
基金：
美国国家科学基金会;
关键词：
dyes; pigments; hydrogels; photocontrolled release; proteins; protein delivery; FUNCTIONAL LEVELS; PROTECTING GROUPS; CAGED SURFACES; LIGHT; HYDROGELS; DELIVERY;
D O I：
10.1002/anie.201308174
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
On the right wavelength: Photolabile molecular units that undergo photocleavage under light of different wavelengths can be used for the independent release of different dyes/proteins from a single, preloaded storage hydrogel (see scheme). The controlled release of each protein allowed them to be delivered sequentially and at experimenter-determined times. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：13803 / 13807
页数：5
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