In Vivo Positron Emission Tomography Imaging of Adenosine A2A Receptors

被引：6
|
作者：
Sun, Meng-Juan [1 ,2 ]
Liu, Fang [3 ]
Zhao, Ya-Fei [1 ,2 ]
Wu, Xiao-Ai [4 ]
机构：
[1] Chengdu Univ Tradit Chinese Med, Chengdu, Peoples R China
[2] Acupuncture & Chronobiol Key Lab Sichuan Prov, Chengdu, Peoples R China
[3] Fourth Mil Med Univ, Xijing Hosp, Dept Lab Pathol, Xian, Peoples R China
[4] Sichuan Univ, West China Hosp, Dept Nucl Med, Lab Clin Nucl Med, Chengdu, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2020年 / 11卷
关键词：
adenosine A2A receptors; positron emission tomography tracers; positron emission tomography imaging; neurodegenerative and psychiatric disease; autoimmune diseases; cardiovascular diseases; PRECLINICAL EVALUATION; SELECTIVE LIGAND; MESSENGER-RNA; POTENT; ANTAGONIST; BRAIN; BIODISTRIBUTION; C-11-PRELADENANT; QUANTIFICATION; RADIOLIGANDS;
D O I：
10.3389/fphar.2020.599857
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
As an invasive nuclear medical imaging technology, positron emission tomography (PET) possess the possibility to imaging the distribution as well as the density of selective receptors via specific PET tracers. Inspired by PET, the development of radio-chemistry has greatly promoted the progress of innovative imaging PET tracers for adenosine receptors, in particular adenosine A2A receptors (A(2A)Rs). PET imaging of A2A receptors play import roles in the research of adenosine related disorders. Several radio-tracers for A(2A) receptors imaging have been evaluated in human studies. This paper reviews the recent research progress of PET tracers for A2A receptors imaging, and their applications in the diagnosis and treatment of related disease, such as cardiovascular diseases, autoimmune diseases, neurodegenerative and psychiatric disease. The future development of A2A PET tracers were also discussed.
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页数：8
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