Bacteriophages and biotechnology: vaccines, gene therapy and antibacterials

被引：224
作者：
Clark, JR [1 ]
March, JB [1 ]
机构：
[1] Moredun Res Inst, Penicuik EH26 0PZ, Midlothian, Scotland
来源：
TRENDS IN BIOTECHNOLOGY | 2006年 / 24卷 / 05期
关键词：
D O I：
10.1016/j.tibtech.2006.03.003
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
In recent years it has been recognized that bacteriophages have several potential applications in the modern biotechnology industry: they have been proposed as delivery vehicles for protein and DNA vaccines; as gene therapy delivery vehicles; as alternatives to antibiotics; for the detection of pathogenic bacteria; and as tools for screening libraries of proteins, peptides or antibodies. This diversity, and the ease of their manipulation and production, means that they have potential uses in research, therapeutics and manufacturing in both the biotechnology and medical fields. It is hoped that the wide range of scientists, clinicians and biotechnologists currently researching or putting phages to practical use are able to pool their knowledge and expertise and thereby accelerate progress towards further development in this exciting field of biotechnology.
引用
收藏
页码：212 / 218
页数：7
相关论文
共 51 条
  • [1] Toward cell-targeting gene therapy vectors: Selection of cell-binding peptides from random peptide-presenting phage libraries
    Barry, MA
    Dower, WJ
    Johnston, SA
    [J]. NATURE MEDICINE, 1996, 2 (03) : 299 - 305
  • [2] Protective immune responses induced by the immunization of mice with a recombinant bacteriophage displaying an epitope of the human respiratory syncytial virus
    Bastien, N
    Trudel, M
    Simard, C
    [J]. VIROLOGY, 1997, 234 (01) : 118 - 122
  • [3] Biotechnological applications of phage and cell display
    Benhar, I
    [J]. BIOTECHNOLOGY ADVANCES, 2001, 19 (01) : 1 - 33
  • [4] Human volunteers receiving Escherichia coli phage T4 orally:: a safety test of phage therapy
    Bruttin, A
    Brüssow, H
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (07) : 2874 - 2878
  • [5] Clark Jason R, 2004, Expert Rev Vaccines, V3, P463, DOI 10.1586/14760584.3.4.463
  • [6] Bacteriophage-mediated nucleic acid immunisation
    Clark, JR
    March, JB
    [J]. FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 2004, 40 (01): : 21 - 26
  • [7] Corbitt AJ, 2000, LETT APPL MICROBIOL, V30, P443, DOI [10.1046/j.1472-765x.2000.00744.x, 10.1046/j.1472-765X.2000.00744.x]
  • [8] Peptides identified through phage display direct immunogenic antigen to dendritic cells
    Curiel, TJ
    Morris, C
    Brumlik, M
    Landry, SJ
    Finstad, K
    Nelson, A
    Joshi, V
    Hawkins, C
    Alarez, X
    Lackner, A
    Mohamadzadeh, M
    [J]. JOURNAL OF IMMUNOLOGY, 2004, 172 (12) : 7425 - 7431
  • [9] Bacteriophage penetration in vertebrates
    Dabrowska, K
    Switala-Jelen, K
    Opolski, A
    Weber-Dabrowska, B
    Gorski, A
    [J]. JOURNAL OF APPLIED MICROBIOLOGY, 2005, 98 (01) : 7 - 13
  • [10] Bacteriophage-mediated protein delivery into the central nervous system and its application in immunopharmacotherapy
    Dickerson, TJ
    Kaufmann, GF
    Janda, KD
    [J]. EXPERT OPINION ON BIOLOGICAL THERAPY, 2005, 5 (06) : 773 - 781
123456