ARE MULTIFOCAL MOTOR NEUROPATHY PATIENTS UNDERDIAGNOSED? AN EPIDEMIOLOGICAL SURVEY IN JAPAN

被引：13

作者：

Miyashiro, Ai ^{[1
]}

Matsui, Naoko ^{[1
]}

Shimatani, Yoshimitsu ^{[1
]}

Nodera, Hiroyuki ^{[1
]}

Izumi, Yuishin ^{[1
]}

Kuwabara, Satoshi ^{[2
]}

Imai, Tomihiro ^{[2
]}

Baba, Masayuki ^{[2
]}

Komori, Tetsuo ^{[2
]}

Sonoo, Masahiro ^{[2
]}

Mezaki, Takahiro ^{[2
]}

Kawamata, Jun ^{[2
]}

Hitomi, Takefumi ^{[2
]}

Kohara, Nobuo ^{[2
]}

Arimura, Kimiyoshi ^{[2
]}

Hashimoto, Shuji ^{[3
]}

Arisawa, Kokichi ^{[4
]}

Kusunoki, Susumu ^{[5
]}

Kaji, Ryuji ^{[1
,2
]}

机构：

[1] Univ Tokushima, Grad Sch Med Sci, Inst Hlth Biosci, Dept Neurol, Tokushima 7708503, Japan

[2] Japanese Multifocal Motor Neuropathy Study Grp, Toyoake, Aichi, Japan

[3] Fujita Hlth Univ, Sch Med, Dept Hyg, Toyoake, Aichi 47011, Japan

[4] Univ Tokushima, Grad Sch Med, Inst Hlth Biosci, Dept Prevent Med, Tokushima 770, Japan

[5] Kinki Univ, Sch Med, Dept Neurol, Osaka 589, Japan

来源：

MUSCLE & NERVE | 2014年 / 49卷 / 03期

基金：

日本学术振兴会;

关键词：

amyotrophic lateral sclerosis; conduction block; diagnosis; multifocal motor neuropathy; prevalence; AMYOTROPHIC-LATERAL-SCLEROSIS; DEPENDENT CONDUCTION BLOCK; ANTIBODIES; CRITERIA; IMMUNOGLOBULIN; DIAGNOSIS; FEATURES;

D O I：

10.1002/mus.23930

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Our objective was to do an epidemiologic survey of patients with multifocal motor neuropathy (MMN) in comparison with those with amyotrophic lateral sclerosis (ALS) in Japan. Methods: In this retrospective study, we examined 46 patients with MMN and 1,051 patients with ALS from major neuromuscular centers in Japan from 2005 to 2009. Diagnosis was based on the European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) and the revised El Escorial criteria. The efficacy of intravenous immunoglobulin (IVIg) was also taken into consideration in the diagnosis of MMN. Results: The ratio of MMN to ALS patients (0-0.10) varied among the centers, but mostly converged to 0.05. The prevalence was estimated to be 0.29 MMN patients and 6.63 ALS patients per 100,000 population. Conclusions: The frequency of MMN patients was around 1 out of 20 ALS patients, and MMN was possibly underdiagnosed in some centers. Muscle Nerve49:357-361, 2014

引用

页码：357 / 361

页数：5

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