Chelator-Free Synthesis of a Dual-Modality PET/MRI Agent

被引：110

作者：

Chen, Feng ^{[1
]}

Ellison, Paul A. ^{[2
]}

Lewis, Christina M. ^{[2
]}

Hong, Hao ^{[1
]}

Zhang, Yin ^{[2
]}

Shi, Sixiang ^{[3
]}

Hernandez, Reinier ^{[2
]}

Meyerand, M. Elizabeth ^{[2
]}

Barnhart, Todd E. ^{[2
]}

Cai, Weibo ^{[1
,2
,3
]}

机构：

[1] Univ Wisconsin, Dept Radiol, Madison, WI 53705 USA

[2] Univ Wisconsin, Dept Med Phys, Madison, WI 53705 USA

[3] Univ Wisconsin, Mat Sci Program, Madison, WI 53705 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 50期

基金：

美国国家卫生研究院;

关键词：

arsenic; cancer; magnetic resonance imaging; positron emission tomography; radiochemistry; IRON-OXIDE NANOPARTICLES; IN-VIVO EVALUATION; TUMOR VASCULATURE; QUANTUM DOTS; ARSENATE; NANOCRYSTALS; ADSORPTION; SEPARATION; PET; METASTASIS;

D O I：

10.1002/anie.201306306

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Old technique, new application: A simple and efficient chelator-free strategy for the synthesis of a novel dual-modality PET/MRI agent has been developed. Labeling of radioarsenic (*AsIII and *As V,*=71, 72, 74, 76) at the surface of superparamagnetic iron oxide nanoparticles (SPIONs) resulted in*As-SPIONs that can be used for simultaneous PET/MRI in cancer diagnosis, lymph-node mapping, and potentially for internal radiotherapy. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：13319 / 13323

页数：5

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