Chelator-Free Synthesis of a Dual-Modality PET/MRI Agent

被引：106
|
作者：
Chen, Feng [1 ]
Ellison, Paul A. [2 ]
Lewis, Christina M. [2 ]
Hong, Hao [1 ]
Zhang, Yin [2 ]
Shi, Sixiang [3 ]
Hernandez, Reinier [2 ]
Meyerand, M. Elizabeth [2 ]
Barnhart, Todd E. [2 ]
Cai, Weibo [1 ,2 ,3 ]
机构：
[1] Univ Wisconsin, Dept Radiol, Madison, WI 53705 USA
[2] Univ Wisconsin, Dept Med Phys, Madison, WI 53705 USA
[3] Univ Wisconsin, Mat Sci Program, Madison, WI 53705 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 50期
基金：
美国国家卫生研究院;
关键词：
arsenic; cancer; magnetic resonance imaging; positron emission tomography; radiochemistry; IRON-OXIDE NANOPARTICLES; IN-VIVO EVALUATION; TUMOR VASCULATURE; QUANTUM DOTS; ARSENATE; NANOCRYSTALS; ADSORPTION; SEPARATION; PET; METASTASIS;
D O I：
10.1002/anie.201306306
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Old technique, new application: A simple and efficient chelator-free strategy for the synthesis of a novel dual-modality PET/MRI agent has been developed. Labeling of radioarsenic (*AsIII and *As V,*=71, 72, 74, 76) at the surface of superparamagnetic iron oxide nanoparticles (SPIONs) resulted in*As-SPIONs that can be used for simultaneous PET/MRI in cancer diagnosis, lymph-node mapping, and potentially for internal radiotherapy. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：13319 / 13323
页数：5
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