Isolation and identification of dihydrochrysanolide and its 1-epimer from Chrysanthemum coronarium L.

被引：20
|
作者：
Lee, KD
Yang, MS
Ha, TJ
Park, KM
Park, KH [1 ]
机构：
[1] Gyeongsang Natl Univ, Div Appl Life Sci, Dept Agr Chem, Chinju 660701, South Korea
[2] Gyeongsang Natl Univ, Res Inst Nat Sci, Chinju 660701, South Korea
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2002年 / 66卷 / 04期
关键词：
Chrysanthemum coronarium L; sesquiterpene lactone; dihydrochrysanolide; 1-epi-dihydrochrysanolide; cytotoxic activity;
D O I：
10.1271/bbb.66.862
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new sesquiterpene lactone (1) was isolated with known dihydrochrysanolide derivatives (2 and 3) from the flowers of Chrysanthemum coronarium L., and their structures were identified by spectroscopic data. The stereochemistry of the epimers (1 and 2) was determined from NOESY data and an X-ray crystallographic analysis. The isolated compounds (1-3) were examined for their cytotoxic activity against such human cell lines as A549, PC-3 and HCT-15.
引用
收藏
页码：862 / 865
页数：4
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