Genomics of Adverse Drug Reactions

被引：45

作者：

Alfirevic, Ana ^{[1
]}

Pirmohamed, Munir ^{[1
]}

机构：

[1] Univ Liverpool, Inst Translat Med, Dept Mol & Clin Pharmacol, Block A Waterhouse Bldg,1-5 Brownlow St, Liverpool L69 3GL, Merseyside, England

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2017年 / 38卷 / 01期

基金：

英国医学研究理事会; 欧盟地平线“2020”; 美国国家卫生研究院;

关键词：

INDUCED LIVER-INJURY; IMPLEMENTATION CONSORTIUM GUIDELINES; HLA-B GENOTYPE; HUMAN-LEUKOCYTE ANTIGEN-B-ASTERISK-5701; ANTHRACYCLINE-INDUCED CARDIOTOXICITY; ABACAVIR HYPERSENSITIVITY; IMPAIRED OXIDATION; PEPTIDE REPERTOIRE; PRECISION MEDICINE; COST-EFFECTIVENESS;

D O I：

10.1016/j.tips.2016.11.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Adverse drug reactions (ADRs) are common, are associated with morbidity and mortality, and are costly to healthcare systems. Genomic factors predispose to ADRs, but these vary depending on the drug, patient, and disease. Genomic testing can not only help to predict and prevent ADRs but can also be used in other ways (diagnosis, closer monitoring of those at risk, pre-emptive genotyping, and understanding of mechanism), all of which will be important in the future to improve the benefit-risk ratio of drugs. In the era of precision medicine, such genomic data will need to be integrated with other forms of data to develop a comprehensive and integrated approach to improve responses to medicines used in patients.

引用

页码：100 / 109

页数：10

共 79 条

[1] Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications [J].

Aithal, GP ;

Day, CP ;

Kesteven, PJL ;

Daly, AK .

LANCET, 1999, 353 (9154) :717-719

[2] Predictive Genetic Testing for Drug-Induced Liver Injury: Considerations of Clinical Utility [J].

Alfirevic, A. ;

Pirmohamed, M. .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2012, 92 (03) :376-380

[3] A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer [J].

Aminkeng, Folefac ;

Bhavsar, Amit P. ;

Visscher, Henk ;

Rassekh, Shahrad R. ;

Li, Yuling ;

Lee, Jong W. ;

Brunham, Liam R. ;

Caron, Huib N. ;

van Dalen, Elvira C. ;

Kremer, Leontien C. ;

van der Pal, Helena J. ;

Amstutz, Ursula ;

Rieder, Michael J. ;

Bernstein, Daniel ;

Carleton, Bruce C. ;

Hayden, Michael R. ;

Ross, Colin J. D. .

NATURE GENETICS, 2015, 47 (09) :1079-+

[4] Correlation of CYP2D6 genotype with perhexiline phenotypic metabolizer status [J].

Barclay, ML ;

Sawyers, SM ;

Begg, EJ ;

Zhang, M ;

Roberts, RL ;

Kennedy, MA ;

Elliott, JM .

PHARMACOGENETICS, 2003, 13 (10) :627-632

[5] Practical recommendations for pharmacogenomics-based prescription: 2010 ESF-UB Conference on Pharmacogenetics and Pharmacogenomics [J].

Becquemont, Laurent ;

Alfrieve, Ana ;

Amstutz, Ursula ;

Brauch, Hiltrud ;

Jacqz-Algrain, Evelyne ;

Laurent-Puig, Pierre ;

Molina, Miguel A. ;

Niemi, Mikko ;

Schwab, Matthias ;

Somogyi, Andrew A. ;

Thervet, Eric ;

Maitland-van der Zee, Anke Hilse ;

van Kuilenburg, Andre B. P. ;

van Schaik, Ron H. N. ;

Verstuyft, Celine ;

Wadelius, Mia ;

Daly, Ann K. .

PHARMACOGENOMICS, 2011, 12 (01) :113-124

[6]

Bjomsson E. S., 2013, GASTROENTEROLOGY, V144, P1419

[7] The effect of pharmacogenetic profiling with a clinical decision support tool on healthcare resource utilization and estimated costs in the elderly exposed to polypharmacy [J].

Brixner, D. ;

Biltaji, E. ;

Bress, A. ;

Unni, S. ;

Ye, X. ;

Mamiya, T. ;

Ashcraft, K. ;

Biskupiak, J. .

JOURNAL OF MEDICAL ECONOMICS, 2016, 19 (03) :213-228

[8] Systems biology approaches to adverse drug effects: the example of cardio-oncology [J].

Brown, Sherry-Ann ;

Sandhu, Nicole ;

Herrmann, Joerg .

NATURE REVIEWS CLINICAL ONCOLOGY, 2015, 12 (12) :718-731

[9] Carbamazepine-Induced Toxic Effects and HLA-B*1502 Screening in Taiwan [J].

Chen, Pei ;

Lin, Juei-Jueng ;

Lu, Chin-Song ;

Ong, Cheung-Ter ;

Hsieh, Peiyuan F. ;

Yang, Chih-Chao ;

Tai, Chih-Ta ;

Wu, Shey-Lin ;

Lu, Cheng-Hsien ;

Hsu, Yung-Chu ;

Yu, Hsiang-Yu ;

Ro, Long-Sun ;

Lu, Chung-Ta ;

Chu, Chun-Che ;

Tsai, Jing-Jane ;

Su, Yu-Hsiang ;

Lan, Sheng-Hsing ;

Sung, Sheng-Feng ;

Lin, Shu-Yi ;

Chuang, Hui-Ping ;

Huang, Li-Chen ;

Chen, Ying-Ju ;

Tsai, Pei-Joung ;

Liao, Hung-Ting ;

Lin, Yu-Hsuan ;

Chen, Chien-Hsiun ;

Chung, Wen-Hung ;

Hung, Shuen-Iu ;

Wu, Jer-Yuarn ;

Chang, Chi-Feng ;

Chen, Luke ;

Chen, Yuan-Tsong ;

Shen, Chen-Yang .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (12) :1126-1133

[10] Effects of a HLA-B*15:02 screening policy on antiepileptic drug use and severe skin reactions [J].

Chen, Zhibin ;

Liew, Danny ;

Kwan, Patrick .

NEUROLOGY, 2014, 83 (22) :2077-2084

← 1 2 3 4 5 6 7 8 →