The Role of Molecular Regulation and Targeting in Regulating Calcium/Calmodulin Stimulated Protein Kinases

被引：16
作者：
Skelding, Kathryn A. [1 ,2 ]
Rostas, John A. P. [1 ,2 ]
机构：
[1] Univ Newcastle, Sch Biomed Sci & Pharm, Callaghan, NSW 2308, Australia
[2] Univ Newcastle, Hunter Med Res Inst, Fac Hlth, Callaghan, NSW 2308, Australia
来源：
CALCIUM SIGNALING | 2012年 / 740卷
关键词：
Phosphorylase kinase; eEF2K; Myosin light chain kinase; CaMKK; CaMKI; CaMKII; CaMKIV; Casein kinase I; Targeting; LIGHT-CHAIN KINASE; ELONGATION FACTOR-2 KINASE; FACTOR-II KINASE; CALMODULIN-BINDING DOMAIN; SITE-DIRECTED MUTAGENESIS; RABBIT SKELETAL-MUSCLE; AMINO-ACID-SEQUENCE; CASEIN KINASE; PHOSPHORYLASE-KINASE; SMOOTH-MUSCLE;
D O I：
10.1007/978-94-007-2888-2_31
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Calcium/calmodulin-stimulated protein kinases can be classified as one of two types - restricted or multifunctional. This family of kinases contains several structural similarities: all possess a calmodulin binding motif and an autoinhibitory region. In addition, all of the calcium/calmodulin-stimulated protein kinases examined in this chapter are regulated by phosphorylation, which either activates or inhibits their kinase activity. However, as the multifunctional calcium/calmodulin-stimulated protein kinases are ubiquitously expressed, yet regulate a broad range of cellular functions, additional levels of regulation that control these cell-specific functions must exist. These additional layers of control include gene expression, signaling pathways, and expression of binding proteins and molecular targeting. All of the multifunctional calcium/calmodulin-stimulated protein kinases examined in this chapter appear to be regulated by these additional layers of control, however, this does not appear to be the case for the restricted kinases.
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收藏
页码：703 / 730
页数：28
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