Development of High Performance Liquid Chomatography Method for Determination of Flurbiprofen and Ranitidine in Bilayer Tablets

被引：0

作者：

Hanif, Muhammad ^{[1
,2
]}

Nazir, Nida ^{[1
]}

Zia, Muhammad U. ^{[1
]}

Chudhary, Bashir A. ^{[2
]}

Abbas, Ghulam ^{[1
]}

Rana, Sadia J. ^{[2
]}

Zaman, Muhammad ^{[2
]}

机构：

[1] GC Univ, Coll Pharm, Faisalabad, Pakistan

[2] Bahauddin Zakariya Univ, Fac Pharm, Multan, Pakistan

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2015年 / 34卷 / 09期

关键词：

Flurbiprofen; high performance liquid chomatography; limit of detection; limit of quantification; ranitidine; INDICATING HPLC METHOD; DOSAGE FORMS; SPECTROPHOTOMETRY; PHARMACOKINETICS; NIMESULIDE; CIMETIDINE; DRUG;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study aims to develop a HPLC method for simultaneous analysis of two complimenting drug formulated as bilayer tablet. Bilayer tablets of flurbiprofen and ranitidine were developed and precise HPLC assay was performed by choosing an isocratic mobile phase (mixture of di-hydrogen potassium phosphate buffer solution (0.2 M) and acetonitrile in the ratio 1:1 as mobile phase) with single wavelength of detection (245 mu) and constant flow rate (1mL/min). Column for separation of drugs used was Gemini C18 column ODS (Dimension 4.6 x 250 mm, 5). The validation parameters like linearity, precision, accuracy, selectivity, and robustness were evaluated successfully. The results suggest that the current method qualifies the selection criteria recommended the guidelines. Regression value of linearity curve was 0.997 and percentage recovery was also from 95 to 105%, while no any robustness was observed in the reported method. Method was found to be applicable in routine analysis (assays) of flurbiprofen and ranitidine bilayer tablets.

引用

页码：1737 / 1742

页数：6

共 19 条

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