The effect of weight loss on anti-Mullerian hormone levels in overweight and obese women with polycystic ovary syndrome and reproductive impairment

被引：67

作者：

Thomson, R. L. ^{[1
,2
,3
]}

Buckley, J. D. ^{[2
,3
]}

Moran, L. J. ^{[1
]}

Noakes, M. ^{[1
]}

Clifton, P. M. ^{[1
]}

Norman, R. J. ^{[4
]}

Brinkworth, G. D. ^{[1
]}

机构：

[1] CSIRO, Adelaide Bc, SA 5000, Australia

[2] Univ S Australia, Sansom Inst Hlth, Australian Technol Network Ctr Metab Fitness, Adelaide, SA 5001, Australia

[3] Univ S Australia, Sansom Inst Hlth, Nutr Physiol Res Ctr, Adelaide, SA 5001, Australia

[4] Univ Adelaide, Robinson Inst, Res Ctr Reprod Hlth, Adelaide, SA 5005, Australia

来源：

HUMAN REPRODUCTION | 2009年 / 24卷 / 08期

基金：

英国医学研究理事会;

关键词：

weight loss; anti-Mullerian hormone; reproductive function; menstrual cyclicity; INHIBITING SUBSTANCE; INSULIN SENSITIVITY; METFORMIN THERAPY; IMPROVEMENT; RESISTANCE; PHYSIOLOGY; FOLLICLES; EXCESS;

D O I：

10.1093/humrep/dep101

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Anti-Mullerian hormone (AMH) has been proposed as a clinical predictor of improvements in reproductive function following weight loss in overweight and obese women with polycystic ovary syndrome (PCOS). This study aimed to assess whether baseline and/or change in AMH levels with weight loss predict improvements in reproductive function in overweight and obese women with PCOS. Fifty-two overweight and obese women with PCOS and reproductive impairment (age 29.8 +/- 0.8 years, BMI 36.5 +/- 0.7 kg/m(2)) followed a 20-week weight loss programme. AMH, weight, menstrual cyclicity and ovulatory function were assessed at baseline and post-intervention. Participants who responded with improvements in reproductive function (n = 26) had lower baseline AMH levels (23.5 +/- 3.7 versus 32.5 +/- 2.9 pmol/l; P = 0.03) and experienced greater weight loss (-11.7 +/- 1.2 versus -6.4 +/- 0.9 kg; P = 0.001) compared with those who did not respond (n = 26). Logistic regression analysis showed that weight loss and baseline AMH were independently related to improvements in reproductive function (P = 0.002 and P = 0.013, respectively). AMH levels did not change with weight loss in both responders and non-responders. In overweight and obese women with PCOS and reproductive dysfunction, a 20-week weight loss intervention resulted in improvements in reproductive function but no change in AMH levels. Clinical Trials Registration Number: ACTRN12606000198527.

引用

页码：1976 / 1981

页数：6