Falsely raised TSH levels due to human anti-mouse antibody interfering with thyrotropin assay - Art no. e27

被引：8

作者：

Krishnan, S. G. S.

Pathalapati, R.

Kaplan, L.

Cobbs, R. K.

机构：

[1] Long Isl Jewish Med Ctr, Dept Nephrol, New Hyde Pk, NY 11042 USA

[2] Bellvitge Hosp, Dept Pathol, New York, NY USA

[3] Metropolitan Hosp Ctr, Dept Internal Med, Div Endocrinol, New York, NY 10029 USA

来源：

POSTGRADUATE MEDICAL JOURNAL | 2006年 / 82卷 / 973期

关键词：

D O I：

10.1136/pmj.2006.049809

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The case of a 39-year-old woman who was referred for weight gain and amenorrhoea is reported. Laboratory evaluation showed high levels of thyroid-stimulating hormone (TSH). The patient was started on increasing doses of levothyroxine for subclinical hypothyroidism. TSH remained persistently raised and the patient became thyrotoxic. Evaluation at another laboratory showed normal levels of TSH, raising the possibility of interfering substances. TSH levels were normalised with the addition of mouse serum to the patient's sample, confirming the presence of human anti-mouse antibodies as the interfering substance in the TSH assay.

引用

页数：3

共 9 条

[1]

Baskin HJ., 2002, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, V8, P457, DOI DOI 10.4158/1934-2403-8.6.457

[2] HETEROPHILIC SERUM ANTIBODIES - A CAUSE FOR FALSELY ELEVATED SERUM THYROTROPIN LEVELS [J].